SULFADIMETOKSIN (Sulfadimethoxinum). 4 - (steam-Aminobenzolsulfamido) -2, 6-dimetoksipirimidin.

     Synonyms : Deposul, Madribon, Madroksin, Agribon, Aristin, Deposul, Depot-Sulfamid, Fuxal, Madribon, Madriquid, Madroxine, Sulfadimethoxine, Sulfastop, Sulxin, Supersulfa, Ultrasulfan, Wysulfa and others.

     White or white with a white crystalline powder kremovatym odourless. Almost nerastvorim water malorastvorim in alcohol, easy-to dilute hydrochloric acid and caustic alkali solutions.

     Refers to a group sulfanilamidnyh long-acting drugs. For antimicrobial action close to sulfapiridazinu.

     Effective against gram and gram bacteria : effect on pnevmokokki streptococci, staphylococci, intestinal wand wand Klebsiella (Baton Friedlander), the causative agents of dysentery; Less active in Protea; The virus is active against trachoma, is not acting on strains of bacteria resistant to other sulfanilamidnym drugs.

     Preparation is relatively slowly absorbed from the gastrointestinal tract. Once inside detected in the blood after 30 minutes, but the maximum concentration achieved through 8 - 12 pm If therapeutic concentration in the blood (adult) indicates admission preparation in one-day dose of 1 to 2 g, and 0.5-1 g O in the next few days.

     Compared with other long-term players sulfanilamidami (sulfapiridazin, sulfamonometoksin) sulfadimetoksin worse crosses the blood-brain barrier, and therefore their use in inappropriate investments meningitis. Other testimony to the application sulfadimetoksina like to sulfapiridazina (acute respiratory infections, pneumonia, bronchitis, tonsillitis, nasal, ear, meningitis, dysentery, inflammatory disease biliary and urinary tract, rozhistoe inflammation, piodermiya, wound infections, trachoma, gonorrhoea, etc. .) . Assign also combined with protivomalyariynimi drugs (with sustainable forms of malaria).

     Applied inside (tablets). The daily dose given at a time. Intervals receptions for 24 h. In milder forms of disease appointed in Day 1 of 1 g, in the following days, 0.5 g; When moderate forms of 2 g and 1 yr Children nominate 25 mg / kg in 1 day and 12 5 mg / kg in the coming days. In severe illnesses sulfadimetoksin recommended for use in combination with antibiotics (penicillin group, erythromycin, or other) or designate other long-term operating sulfanilamidy.

     Possible complications and contraindications such as when applying sulfapiridazina.

     Method of issuance : powder; Tablets of 0.2 and 0.5 grams in a package of 10 pieces.

     Storage : List B. In the dark spot.

     Sulfadimetoksin belongs to the ages <<Levosin>> (see Levomitsetin).

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