STROFANTIN K (Strophanthinus K).

     Strofantin K-mixture cardiac glycosides available from seed strophanthus Combe, and contains mostly strofantin- b K and K-strofantozid.

     K-strofantin- b consists of aglikona strofantidina and sugar balance (glucose and tsimaroza); K-strofantozid is more one of a glucose-D.

     Strofantin K-white or white with a slightly yellowish sheen chip metallic powder. It is soluble in water and alcohol. In 1 g contains LED 43000 58000 or 5800-7100 KED.

     He is a principal representative "polar" cardiac glycosides.

     Strofantin characterized by high efficiency, speed and short duration of action. The effect when seen through intravenous 5 - 10 minutes, reaching a peak after 15 min-PC. Especially expressed a strofantina systolic effect; He had relatively little impact on the frequency of heart and conductivity of a pencil Gisa.

     The drug belongs to malostoykim glycosides; When administered it ineffectual. Virtually no cumulative effect, but if the patient previously assigned other drugs cardiac glycosides, it is necessary to intravenous strofantina a break, as a strofantina be in addition to the effect of accumulated in the body glycosides lapidary and cause toxic effects.

     Time break-an average of about 5 days, but if he were treated with drugs with a strong cumulative effect (digitoksin), a break is to be expanded so 10 to 14 days.

     Applied with acute heart problems, including on the grounds of acute myocardial infarction; With heavy forms of chronic circulatory failure II and III level, especially when neeffektiv of treatment drugs lapidary. Strofantin by weak effect on nerve function wandering may be nominated in cardiac decompensation with normal heart rhythm, or the frequency of blinking bradisistolicheskay predserdy.

     In tahikardicheskoy form mertsatelnoy keep more efficient and izolanid digoxin.

     Enter strofantin in veins in the form of 0,025% solution typically 0.25 mg (1 ml), less than 0.5 mg. Solution strofantina to throw in the pre-10-20 ml of 5%, 20% or 40% solution of glucose or isotonic sodium chloride solution. Enter slowly (for 5 - 6 minutes), as well as the rapid introduction could cause shock. Enter once (rarely 2 times) a day. You may enter solution strofantina drip in 100 ml isotonic sodium chloride solution, or 5% glucose solution. In a drip there are fewer toxic effects.

     If it is impossible to intravenous sometimes strofantin designate intramuscularly. To reduce pain (intramuscular injections dramatically painful) pre-enter 5 mL 2% solution of novocaine, then through the same needle-needed dose strofantina, divorced in 1 ml 2% solution of novocaine. With the introduction intramuscular dose increases of 1, 5 times.

     Higher doses strofantina K adult admission : single 0.0005 g (0.5 mg), 0,001 g daily (1 mg) or 2 and 4 ml 0.025% solution.

     Because of the activity and rapid action strofantina requires caution and precision in the dosage and testimony.

     In strofantina overdose may appear arrythmia, bigeminiya, dissociation rhythm; In these cases should be reduced to a regular dose and increase the intervals between individual infusion, appoint drugs potassium. In sharp deceleration pulse injections cease. There are nausea and vomiting.

     Contraindications : sharp organic changes of heart and vascular, acute myocarditis, endocarditis, expressed cardiosclerosis. Caution is needed when thyrotoxicosis and predserdnoy arrythmia because of the possibility of its transition to predserdy blinking.

     Product : 0,025% injection in 1 ml ampoules.

     Storage : List A. In the dark spot.

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