STREPTODEKAZA injection (Streptodecasum pro injectionibus).

     The drug streptokinase, which belonged to the group "immobilized" enzymes.

     Has fibrinoliticheskoe prolonged effect.

     Powder or porous mass (in the form of cakes) white or white with a yellowish sheen color. Rastvorima easily in water and isotonic sodium chloride solution.

     The preparation was based on the immobilization of streptokinase water-soluble polysaccharide matrix of nature and capable of living long active in the circulatory system. One introduction average therapeutic dose fibrinoliticheskoy enhances the activity of blood in the 48-72 h.

     Drug activity is expressed in units fibrinoliticheskih (FE).

     According to the testimony of the body and the use of the drug is similar to other drugs streptokinase (see Streptoliaza).

     Applied streptokinase for the treatment of acute peripheral arterial or venous thrombosis (except where indicated emergency surgery), peripheral flebotromboza; Acute pulmonary artery in the lung or in cases of recurrent thrombosis small branches; Acute myocardial infarction in 1 - 2 nd day diseases during his or recurrent; retromboze after trombektomii.

     There, on the use of streptodekazy with ischaemic stroke.

     In ophthalmic practising streptodekazu thrombosis in the central artery and vein eyes.

     Enter intravenous streptokinase struyno usually in a dose 300000 FE (test dose), and then an hour later, in the absence of side effects are more struyno (within 1 to 2 minutes) has 2700000 FE (total dose 3000000 FE) at the rate of 300 000-600000 FE minute.

     In these doses, the drug is a significant and prolonged increase in blood fibrinoliticheskoy activity, increased content and plazmina plasminogen activator, has expressed therapeutic effect.

     Streptodekaza therapeutic doses little impact on blood clotting.

     To prevent retromboza appropriate combination therapies streptodekazoy and incidents. Since the end of January-four days after the treatment dose streptodekazy (FE 3000000), introducing heparin ED 40000 per day (ED 10000 for every 6 h) within 7 to 10 days.

     Re-introduction streptodekazy permitted no earlier than three months after treatment for the format, and only after the study reveals streptococcal antibodies. If necessary, re-introduction usually produced after 6 months.

     To treat venous thrombosis retina to impose streptodekazu retrobulbarno on 30000 - 50000 in FE 0.2 - 0.3 ml isotonic sodium chloride solution at intervals of five days. In between injections impose retrobulbarno heparin and dexamethasone.

     In applying streptodekazy that can be allergic reactions, and when combined with heparin haemorrhagic complications.

     Application streptodekazy contraindicated in gemorragicheskik diathesis, krovotecheniyah, gastric ulcer and duodenal ulcer, in the day after four operations and delivery of acute streptococcal infection, sepsis, endocarditis, acute inflammatory diseases of the abdominal cavity (pancreatitis, cholecystitis, appendix, etc.) up to 18 weeks of pregnancy, high arterialnam pressure active tuberculosis process of malignant tumors, allergies to fibrinoliticheskie drugs in the past; diabetes (medium and heavy over), Bronchoectatic disease with the destructive process, liver cirrhosis, urolithiasis under increasing expressed atherosclerosis.

     Caution should be observed in applying streptodekazy from those middle-aged and elderly.

     Product : in the hermetically ukuporennyh 10 ml size bottles containing 1500000 or 1000000 FE streptodekazy (in the pack to 2 bottle). The contents of a bottle dissolve immediately before application of 10-20 ml isotonic sodium chloride solution.

Materials allowed to copy only with the active hyperlink to the handbook of medicines