STAVUDIN (Stavudine).

     1-(2,3 - Didezoksi-? -D- glitseropent -2 - enofuranozil) Thymine.

     Synonym : Zerit, Zerit.

     White or not white crystalline powder. Mg in the water.

     In cell organism fosforiliruetsya to stavudine triphosphate, which suppresses the activity of reverse transcriptase, which led to the synthesis of viral RNA.

     When ingestion rapidly and completely absorbed, bioavailability of approximately 85%, with max-1 h, T? 1,7-3,5-h (in violation of kidney function-to 8 h); display kidneys.

     Applied with HIV.

     Assign the interior (for 1 hour before eating) adults weighing up to 60 kilograms of 0.03 g, 60-kg and over 0.04 grams of children up to 30 kg-1 mg / kg, 30 kg and over-0.03 g every 12 h.

     Possible side effects : peripheral neuropathy, diarrhoeal phenomenon, anorexia, disruption of the pancreas and liver, musculo-skeletal, sky, neutropenia, thrombocytopenia, allergic reactions, etc.

     Contraindications to liver failure, pp.

     Method of issuance : Capsule to 0,015; 0.02; 0.03 and 0.04 g (N. 14, 60); Powder to 0.1% solution (suspension) for the reception inside.

     Storage : List B.

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