SPIRONOLAKTON (Spironolactonum). g-Lakton-3- (3-oxo-7-tioatsetil a 17-b-17-androstene oksi-4- a mud) propionic acid.

     Synonyms : Aldakton, Veroshpiron, Aldactone A Spironolactone, Verospiron.

     Spironolactone is kaliysberegayuschim diuretikom distinct mechanism of action and triamterena amilorida. Provided spironolaktonom diuretichesky effects associated with antagonism towards adrenal cortex hormone-aldosterone (See Drugs adrenal cortex and their synthetic analogues.) .

     Aldosterone is mineralokortikosteroidom; He participates in the regulation of the concentration of electrolytes in the body; To reverse intake of sodium ions in kidney Channel lowering sodium in the urine for increased allocation of potassium ions. As mineralokartikosteroid aldosterone much more active than dezoksikortikosteron : the ability to delay for sodium it dezoksikortikosteron 25 times and 300 times more active than cortisol (hydrocortisone).

     Spironolactone is a competitive antagonist of aldosterone on the impact of distal nefronov divisions; Drug increases for sodium, but also reduces the allocation of potassium and urea, lowers titruemuyu acidity of urine. Natriyureticheskoe to make greater diureza. Owing to the provision of sodium ions, spironolactone may have anti-hypertensive effect, but the effect of instrumentation.

     Spirolakton diureticheskoe applied as a means of swelling associated with heart irregularities in astsitah in connection with liver cirrhosis, with nefroticheskom syndrome and swelling of different origins. Diuretichesky effect spironolaktona expressed moderate and usually manifests itself in the 2 - 5-day treatment.

     To expedite and strengthen diureticheskogo effect simultaneously appoint (in the conventional dose) Other Diuretics (derivatives benzotiadiazina, furosemide, etakrinovuyu acid, etc.), while significantly increasing the allocation of sodium and potassium withdrawal delayed. With low diureticheskom effect can be further appointed Glucocorticosteroids. In nefroticheskom syndrome first Glucocorticosteroids are, and if necessary, further spironolactone.

     Spironolactone especially shown in gipokaliemii syndrome caused by other diuretikami, and the sensitivity to drugs lapidary due gipokaliemiey.

     While the application spironolaktona (veroshpirona) in infectious allergic bronchial asthma. Preparation is especially shown patients with bronchial asthma, pneumonia pravoserdechnoy failure.

     Spironolactone also used in paroxysmal mioplegii. The effect may be related to a delay of potassium ions from the body.

     It also apply spironolactone in adjuvant therapy parkinsonizma. The reason is evidence that, firstly, if there parkinsonizme secondary adrenal insufficiency glyukokortikoidnoy functions, and secondly, in patients parkinsonizmom has increased excretion of urine aldosterone. In applying spironolaktona expressed more influence on drozhatelny component, to a lesser extent, for rigidity.

     Is spironolactone inside. Daily intake varies from 0.05 to 0.3 g. Normally it is 0.1 - 0.2 g (2 - 4 admission). When a lower dose effect necessary to 0,075 - 0,025 grams per day.

     In parkinsonizme appoint a 20-day course (with a break 4 - 5 months); In hypertensive - 0,025 grams of 3 - 4 times a day to strengthen action hypotensive drugs.

     For patients with hypotension and standard product is not diminishing AD.

     In some cases, the application may be spironolaktona nausea, dizziness, drowsiness, ataxy, skin rashes; Occasionally meets reversible form ginekomastii. It should take into account the possibility giperkaliemii and giponatriemii. During the treatment should not be given to patients preparations containing potassium.

     Contraindications : acute renal failure, nefroticheskaya stage chronic nephritis, azotemiya. In connection with a possible giperkaliemiey should be careful in appointing a drug to patients with incomplete atrioventrikulyarnoy blockade. There should be appointed spironolactone with drugs that cause ginekomastiyu.

     It should also appoint drug in the first three months of pregnancy.

     Product : pills to 0,025 g (25 mg).

     Storage : List B.

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