SPIRAPRIL (Spirapril).

     (8S) -7-[(S) - N [(S) -1 - Karboksi-3- fenilpropil] Alanine] -1,4 - ditia-7- azaspiro [4,4] nonan-8- 1-carboxylic acid - ethyl ether.

     Synonyms : Kvadropril, Renpress, Quadropril, Renpress.

     Alaninsoderzhaschy ACE inhibitor for long periods.

     Quickly and completely absorbed in the digestive tract, bioavailability varies from 28% to 69%, with max of 1 h, T? 40-h; being in the liver biotransformation education spiraprilata active metabolite; devoted primarily with bile.

     Applied with arterial hypertension (including hypertension with kidney failure), and congestive heart failure.

     Assign inside tablets (not liquid) to 0,003-0,006 grams (3-6 mg), 1 per day (morning).

     Possible side effects : adults, oppression blood, kserostomiya, neuralgia, drowsiness, dry cough, giperkaliemiya, giperurikemiya, allergic reactions, etc.

     The drug is contraindicated in severe renal failure, primary giperaldosteronizme expressed giperkaliemii, pregnancy and breastfeeding.

     Product : pills to 0,006 g (6 mg) (N. 10, 30).

     Storage : List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines