SOTALOL (Sotalol).

     4? - [1-Oksi-2- (izopropilamino) ethyl] metansulfonanilid.

     Available as hydrochloride.

     Synonyms : Gilukor, Darob, Loritmik, Sotageksal, Sotaleks, Tahitalol, Berlex, Betapace, Darob, Gilucor, Loritmic, Sotahexal, Sotalex, Tachytalol.

     The white crystalline powder. Mg in water, ethanol and propylene.

     Is indiscriminate blokatorom? 1 and? 2-adrenoreceptor, at the same time of Electrophysiology properties of the complications of Class III drugs.

     Like other? - Adrenoblokatoram (enumerated in antiaritmikam Class II), sotalol reduced the frequency and force of heart slows atrioventrikulyarnuyu conductivity; However, as amiodarone and other antiaritmiki III class, it blocks potassium currents slow straightening, prolonging the action potential and absolute refrakterny during all of performing heart. These features of sotalol have reason to believe it antiaritmikom III and Class II (mixed mechanism of action).

     When ingestion rapidly and completely absorbed, bioavailability of approximately 100%, T? - 7-18 h; little is biotransformation in the liver, kidneys predominantly displayed.

     Assign mainly zheludochkovyh tahiaritmiyah, including Poly fibrillation, ventricular tachycardia, tachycardia in patients with thyrotoxicosis; Rarely, if supraventrikulyarnyh tahiaritmiyah.

     As published in foreign medical literature that the effectiveness of sotalol in long-term use significantly (2 times in the 4-year observation) exceeded the cumulative effect of the various antiaritmikov I class on relapse prevention is not only dangerous zheludochkovyh departments, but also of so-called "aritmicheskoy" and "cordial" death and death from all causes.

     It may also be used with strokes tension (especially in combination with tahiaritmiyami) and arterial hypertension.

     Applied usually inside in the form of tablets (to food, squeezed a small amount of water) in the dose of 0.04 g of 2-3 times a day. If necessary, add a single dose (with an interval of 2-3 days) before 0,08-0,16 g, and depending on the effect and endurance to 0,24-0,32 2 g per day. Treatment for under close medical supervision (Heart).

     When injected paroksizmalnyh keep on 0,02-0,12 g for 10 minutes under the supervision of the ECG and blood pressure, if necessary re-enter at intervals of six hours

     Possible side effects are the same as those of other indiscriminate? - Adrenoblokatorov (see Anaprilin). Sometimes there aritmogennoe Effects (tachycardia type "pirouette").

     Sotalol is contraindicated in heart failure functional class IV, kardiogennom shocked by the arterial Hypotension, atrioventrikulyarnoy blockade II-III extent sinoatrialnoy blockade syndrome weakness sinusnogo hub expressed aetiology, elongated interval syndrome Q-T, tachycardia type "pirouette", as well as ( because of the embargo? 2-adrenoreceptor) in bronchial asthma and other obstructive diseases of the respiratory tract and blood vessels obliteriruyuschih diseases.

     There is a need to be cautious about the appointment of patients that have recently experienced myocardial infarction, diabetes, feohromotsitome. If the drug is used renal function in a reduced dose.

     In the absence of evidence of life is not appointed during pregnancy and lactation period.

     If the dose sotalol diminish gradually.

     In applying the drug can prevent violation of motor and mental reactions, and therefore must be careful in his appointment transport drivers, machine operators and appliances, etc.

     Method of production : tablets of 0.08 and 0.16 g (N. 20, 30, 50); 1% injection in ampoules of 4 ml (N 5).

     Storage : List B.

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