SIZOMITSINA SULFAT (Sisomycini sulfas).

     Sol (sulfate) of the antibiotic group aminoglikozidov formed in the process of life Micromonospora inyoensis or other related microorganisms.

     Synonyms: Extramycin, Pathomycin, Rickamysin, Siseptin, Sisomin.

     White or white with a yellowish tinge or rosy powder. Easy soluble in water. Apply a 1% or 5% solution.

     Sizomitsin with broad antimicrobial actions. Active for most gram and gram microorganisms, including stafilokokkov resistant to penicillin and metitsillinu. For close to the range of gentamicin, but more active.

     Enter intramuscularly and intravenously. With the muscles rapidly absorbed, the peak concentration in blood is detected after 30 h -1 min; Therapeutic concentrations in the blood persist for 8 - 12 hours With the introduction of drip peak concentrations observed after 15 to 30 minutes.

     The product is not penetrate through cross the blood-brain barrier. When meningitis found in the spinal fluid.

     There were unchanged to the kidneys. For patients with kidney function violation vydelitelnoy drug concentration in blood is trapped at high levels.

     Apply sizomitsina sulfate with heavy usage septic infections (sepsis, meningitis, peritonitis, septic endocarditis), severe inflammatory diseases of the respiratory system diseases (pneumonia, empiema aswellaspleuralplaques, Abscess light), kidney and urinary infections ways, infected burns and other diseases caused by most micro gram or gram associations and gram agents.

     Enter sizomitsina sulfate intravenously or intramuscularly (kapelno). Single dose for adults with kidney and urinary tract infections to 1 mg / kg per day, 2 mg / kg (2 admission). With heavy usage septic diseases and inflammatory diseases of the respiratory tract, single dose of 1 mg / kg per day to 3 mg / kg (3 admission). In especially serious cases in the first 2 to 3 days and 4 impose mg / kg / day (maximum dose), followed by lower doses up to 3 mg / kg (3 to 4 admission). Daily dose for infants and children up to 1 year to 4 mg / kg (maximum dose of 5 mg / kg), from 1 year to 14 years, 3 mg / kg (maximum of 4 mg / kg) over 14 adult dose. Newborn daily dose of introducing 2 admission, the rest of the children in the 3 admission. Children young drug appointed only on condition of life. The duration of treatment in adults and children 7 to 10 days.

     Solutions sizomitsina sulfate train just before the introduction. For intravenous drip to add a single dose of antibiotic for adults 50-100 ml of 5% glucose solution and isotonic sodium chloride solution and 30-50 ml of 5% glucose solution for the children. The speed of adults 60 drops per minute, children 8 to 10 drops per minute. Intravenous infusions prozvodyat usually within 2 to 3 days, then move on intramuscular injection.

     Adverse events with similar sizomitsina so in the application of other Antibiotic aminoglikozidov (nefro- ototoksichnost and, in rare cases, violations of nerves muscle conduction). With intravenous a possible development periflebitov and flebitov. In rare cases, allergic reactions occur (skin rash, itching, swelling).

     Contraindications are the same as for other Antibiotic aminoglikozidov.

     Form release: 5% solution (50 mg / ml) in the ampoule and 1; 1, 5 and 2 ml for adults and 1% solution (10 mg / ml) in the ampoule and 2 ml for children.

     Storage: List B. In sheltered from the world scene at room temperature.

Materials allowed to copy only with the active hyperlink to the handbook of medicines