Simvastatin (simvastatin)


SIMVASTATIN (Simvastatin).
     1,2,3,7,8,8-to-N-3, 7-dimetil-8- [2 - (tetragidro-4- oksi-6- oxo-2 H piran-2- mud) ethyl] -1 - naftalenil -2,2 - dimethyl butanoat.
     Synonyms : Vazilip, Zokor, Simvor, Simgal, Simgal, Simvor, Synvinolin, Vazilip, Zocor.
     White or not white crystalline powder. Almost nerastvorim water well soluble in chloroform, methanol and ethanol.
     On chemical structure and the mechanism of close to lovastatinu.
     Like the latter, a prolekarstvo (activity seen after metabolism in the body with education? - Oxyacids).
     When applied NCEP (with the lack of therapeutic effect of the diet), a combination of NCEP and gipertriglitseridemii, IBS, atherosclerosis, for the prevention of myocardial infarction and stroke.
     As published in foreign medical literature that the long-term (within 5.5 years) admission simvastatina patients with strokes or stress experienced myocardial infarction led to the favourable development of reliable blood plasma lipid profile (mostly by lowering cholesterol levels LPNP), and improve survival of patients.
     Assign the inside, starting with doses 0.01 g (10 mg) 1 every evening during dinner. After about one month to increase the dose of 0.04 g (1 times a day-night or two of receiving 0.02 grams for breakfast and dinner). Most appoint 0.02 1 every evening. In dose 0,08 g per day has expressed gipotriglitseridemicheskoe effect. Clinical pronounced effect usually develops after 2 weeks and a maximum of 4-6 weeks through.
     Possible side effects : neuralgia, an increase of hepatitis and pancreatitis, mialgiya, myo, anemia, depression, parestezii, peripheral neuropathy, allergic reactions, etc.
     Indications are the same as those lovastatina.
     Nicotinic acid (in high doses), immunosuppressants antifungal group Azola (ketonazol, Itraconazole) increase the risk of developing and myo rabdomioliza.
     Enhance effects of proximity and anti gepatoksicheskoe of alcohol.
     Method of issuance : pills to 0,005; 0.01; 0.02; 0.04 and 0.08 g (N. 14, 28).

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