SILDENAFILA TSITRAT (Sildenafil citrate).

     Citrate 1-[[3-(6,7-oxo Digidro-1- metil-7- propyl - 1 H-pyrazol [4,3-A] pirimidin-5- d) 4-etoksifenil] sulphonyl] piperazine.

     Synonym : Viagra, Viagra.

     Originally proposed as a means of cardio vascular, but proved ineffective; However, some patients who received it noted an increase in male sexual potency; The preparation has been studied in this direction, and the data confirmed Caverta (under the name "Viagra") received medical use.

     Mechanism of action is still not clear enough. In terms of biochemistry major importance is the ability sildenafila selective inhibition of enzyme activity fosfodiesterazy type V exercising inaktivirovanie cyclical guanozinmonofosfata (H GMF) involved relaxation smooth muscles cavernous body and improves blood circulation penis. Caverta no direct relaxation of the receptacle cavernous body, it also enhances the effect sosudorasshiryayuschy released in the sexual stimulation of nitric oxide (NO) in this tissue. Obviously, physiologically play spinal cord stimulation, especially in the light of data on the effectiveness of drug potency of the violations related to spinal cord injury.

     When ingestion rapidly and completely absorbed, bioavailability of 40%, S-60 minutes max, T1 / 2 to 4 hours; Under intense biotransformation in the liver with the formation of active metabolite, displayed mainly in the form of feces metabolites.

     Assign inside (in the form of tablets) normally dose of 0.05 g (50 mg) for 1 hour before sexual intercourse. Depending on the effect of dose can be reduced to 0,025 grams, or up to 0.1 g. The maximum recommended dosage of 0.1 g of 1 times a day.

     According to reports, medication is usually well. Possible side effects : headache, dizziness, neuralgia, increased peripheral vascular (tidal), and violation of light tsvetovospriyatiya, clarity of view, arthralgia and mialgiya.

     The drug is not suitable for serious somatic diseases.

     Vascular draw attention to the dangers of the drug patients who use nitrates (ie a wide range of patients with IBS). The messages recently received nitrate to contraindications for the appointment of Viagra. Endocrinologists recommend to patients suffering from diabetes, consult a cardiologist and an ophthalmologist. In general, to use the drug on the advice of a doctor.

     Product : pills to 0,025; 0.05 and 0.1 g (25; 50 or 100 mg) (N. 1, 4, 8, 12).

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