SERTRALIN (Sertraline).

     (1S, 4S) -4 - (3,4 - dihlorfenil) -1,2,3,4-methyl tetragidro-N- NAPHTHYLAMINE hydrochloride.

    

     Synonym: Zoloft, Zoloft.

     The white crystalline powder. Poor soluble in water and alcohol izopropilovom, soluble in ethanol.

     Refer to the "balanced" drugs dominated anksioliticheskih properties.

     Active selective inhibitor reverse takeover neyronalnogo serotonin; Little effect on the reverse takeover noradrenalina and dofamina. Specific Power to adrenergic, M-holinergicheskim, GAMKergicheskim, dofaminergicheskim, gistaminergicheskim, BZ, and serotoninergicheskim receptors is not. It provides inhibition effect on MAO activity.

     When you receive a product inside quickly and completely absorbed, with max of 4-8 h; Being in the liver biotransformation to form active metabolite N-desmetilsertralina, T1 / 2 sertralina and active metabolite - 26 and 62-104 h; Stable blood plasma sets about seven days after the start of the reception (of seniors in 2-3 weeks); output from the body with the urine (primarily in the form of metabolites) and faeces.

     Apply mainly for the treatment of severe depressive condition.

     Assign inside. Normal adult dose of 0.05 g (50 mg) per day (single admission morning or evening, regardless of the meal), if necessary and good portability of gradually increasing to 0.05 g at intervals of one week. The maximum daily intake for adults - 0.2 g (200 mg). For children initial dose of 0,025 g (25 mg) a day, if necessary, it can be increased through one week to 0.05 g (50 mg) a day.

The maximum daily intake for children was 0.2

     Initiation of a drug usually through 2-4 weeks.

     Sertraline is usually well tolerated by. In the absence of antiholinergicheskogo is atony bowel, bladder. There may fall, giperkinezy, tachycardia, swelling, bronchoconstriction, cough, arthralgia, and allergic skin reactions.

     The product contraindications to breast feeding and childhood.

     We should not take Sertraline with MAO inhibitors, Tricyclic antidepressants, tranquilizers, derivatives sulfonilmocheviny, kumarinovymi anticoagulants, dinoksinom. When receiving the drug alcohol is not permitted.

     Must be careful in appointing a drug to people whose work requires more attention.

     Form release: pills to 0.05 and 0.01 g (50 and 100 mg) (N. 14, 28).

     Storage: List B.

Materials allowed to copy only with the active hyperlink to the handbook of medicines