RUBOMITSINA HYDROCHLORIDE (Rubomycini hydrochloridum).

     Antibiotic substance produtsiruemoe microorganism Actinomyces coeruleorubidus.

     Synonyms: Cerubidin, Daunoblastin, Daunomycin, Daunorubicin, Rubidomycine.

     The product is structured glikozida and hydrolysis falls into aminosahar daunozamin, soluble in water and insoluble aglikon.

     Refers to a group of antibiotics antratsiklinovogo series. By the same type of doxorubicin and karminomitsin.

     Rubomitsin (published as hydrochloride) is a crystalline powder or mass red. Gigroskopichen. Soluble in water and alcohol.

     The product has antibacterial and antitumor activity. Antitumor effects associated with blocking matrix activity of DNA in the system POLYMERASEII DNA and DNA-dependent RNA POLYMERASEII that breach the synthesis of nucleic acids.

     Apply in horiokartsinome, acute leukemia, retikulosarkome.

     Enter intravenously. In subcutaneous and vnutrimyshechnom a possible infiltraty and necrosis.

     Enter drug adult daily 0.8 mg / kg for 5 days. After seven to 10 days interval (if the patient is well-deferred treatment) to impose 0.5 0.8 mg / kg / day for 3 to 5 days. With good portability can be increased to a daily dose of 1 mg / kg. Treatment can continue the same dose, with the same breaks.

     Children in the first five days appoint daily 1 mg / kg. With good portability hold after 7 - 10 days interval, 2 nd round of treatment: drug designate a day for 1, 0, 1, 5 mg / kg, followed by intervals of 2 to 3 weeks may go to West, 4 th and 5 th cycles.

     Perhaps a combination of rubomitsina protivoopuholevymi with other drugs (tsiklofosfan, Methotrexate, Mercaptopurine etc.), radiation therapy.

     Rubomitsin in doses close to the treatment can cause granulotsitoneniyu and thrombocytopenia. When leukemia since the first introduction of cells in the peripheral blood rapidly decreases more slowly declining number of platelets. Lower blood and platelets usually for the next 8 to 10 days after the introduction of the drug. In overdose are nausea and sometimes vomiting, headache, loss of appetite. To reduce these phenomena appoint Diphenhydramine or other protivogistaminny product, with nausea and vomiting, or aminazin etaperazin. When expressed diarrhoeic phenomena, reduce single dose, lengthened interval (24 hours) between injections.

     When fungal defeat oral mucosa appoint nystatin or caramel dekamina. In overdose can be observed violations of the heart (kardiotoksichnosti phenomenon).

     Contraindications preparation with a sharp depletion of the patient, the number of tuberculosis less than 3, 5 x 10 9 / L and platelets 150 x 10 9 / L (except leukemia), and organic defeat heart. After other treatment methods appointment rubomitsina possible after the restoration of blood, but no earlier than two weeks.

     Form release: in vials of 0.02 and 0.04 g (20-40 mg of the drug per p benchmark for chemically pure rubomitsina hydrochloride).

     Before using dissolve the contents of the vial of 10 ml isotonic sodium chloride solution.

     Storage: List A. In a dry, sheltered from the world scene at room temperature.

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