PROLONGIROVANNYE MEDICINAL FORMS NITROGLITSERINA

     Prolonged dosage forms nitroglycerin is widely used for chronic forms of IBS, to prevent strokes, and chronic heart failure.

     Tablets or capsules polymeric media (including nitroglycerin in microcapsules, granules) for oral delivery. Effect develops gradually and usually persists for several hours.

     On deystviyu6 these drugs essentially similar to each other, a choice of one or the other determined by the content of nitroglycerin, variations in the speed of onset and duration of effect, individual portability.

     Domestic drug "Trinitrolong" issued in the form of polymer films, in a room at the mucous membrane gums relatively quickly, and long-term.

     Prolonged drugs for transdermalnogo (?) issued in the form of ointments and plasters.

     Pills nitrogranulonga (Ta bulettae Nitrogranulongi).

     Nitrogranulong a micro containing 100 grams of nitroglycerin 8 grams etiltsellyulozy 24, 4 g, 40.8 g atsetilftalattsellyulozy and other substances to the total mass of 100 From mikrogranul prepare tablets, coated (white), with one pill 0.0029 or 0.0052 g nitroglycerin (Ta bulett s e t Nitrogranulongi 0.0029 0.0052 on bducta e).

     A tablets nitrogranulonga polymeric compounds and coated surface, creating conditions for the relatively slow release of nitroglycerin and extended his actions. The drug is intended for reception inside.

     Applied to prevent strokes. Is the inside of food; Proglatyvayut not liquid, squeezed water. Step moving in the first hour after administration and lasts for up to 6 hours or more.

     In light cases appoint two tablets of 0.0029 g (2, 9 mg) 2 3 times a day; In more severe cases, and 1 - 2 pills to 0.0052 g (5, 2 mg) 2 - 3 times a day (no more than 2 tablets at reception and six tablets a day).

     The maximum single dose tablets admission to 2, 9 mg of 11.6 mg, or 4 pills, the daily dose of 12 tablets (34, 8 mg).

     Possible side effects and contraindications are the same as for other drugs nitroglycerin (tablets and capsules).

     Product : pills to 0.0029 and 0.0052 g (2, 9 and 5, 2 mg) in 50 banks glass pieces.

     Storage : List B. In dry, the dark place at room temperature.

     Trinitrolong (Trinitrolong). Polymer plates (film) oval containing 0,001 grams (1 mg) nitroglycerin, painted in green, or 0,002 grams (2 mg) nitroglycerin, painted with a white, the other in the light green.

     Applied as prolonged drug nitroglycerin for the prevention, and for cupping the strokes. Inclusion of nitroglycerin in the film biorastvorimogo polymer ensures rapid offensive effect (1 to 2 min) and prolonged action (until April 3 h).

     Preparation is especially convenient for use in patients with frequent attacks strokes voltage.

     Applied plate trinitrolonga by application to the mucous membrane of the mouth. Pre-defined single individual dose, which depends on the speed of resorption plates. To this end, in the mucous membrane of the mouth, such as the top of Yakutia gums or small indigenous teeth, the doctor runway polymer plate-media-without nitroglycerin, determines the time of its full resorption, and then selects the plate with the number (0,001 or 0 , 002 g) nitroglycerin to ensure continuous and optimal therapeutic effect for the full resorption plates. The elected version of the album with a dose of nitroglycerin 0,001 grams (1 1 5 h resorption), or 0,002 grams (2 to 3 h resorption) in the future apply to the patient, nakleivaya her gum and clutching a finger.

     The severity and duration vary in the different patients. To accelerate the effect of the patient may Language "polizyvat" plate. If it is necessary to terminate the preparation, a plate removed. The bar is recommended to cause mucous membrane after eating.

     Product : in a package of 10 and 50 plates.

     Storage : List B. In dry, the dark place away from the fire.

     Also, a medicinal form trinitrolonga reception inside capsules containing 3, 6 or 12 mg nitroglycerin in the capsule. Capsule proglatyvayut not liquid, ?high small amount of water. Is 3 - 4 times a day. The maximum single dose of 12 mg, the maximum daily, 36,332 mg.

     As the operation is similar to nitrogranulongom.

     Sustak (Sustac) *.

     Mikrokapsulirovannaya medicinal form of nitroglycerin prolonged action in the form of tablets containing 2, 6 mg nitroglycerin (sustak- photo), or 6, 4 mg nitroglycerin (sustak- forte).

     Tablets containing microcapsules with nitroglycerin, some of which quickly dissolves when administered and works in about 10 minutes, the other often dissolves slowly and operates in a few hours.

     Applied to prevent strokes with chronic coronary insufficiency.

     Assign inside; Proglatyvayut not liquid and not razlamyvaya pills; ?high small amount of water.

     A selection of individual doses. There is evidence that after the end of the positive effects of a single dose, there may be a "effect aftereffect" deteriorating hemodynamic performance. So instead of two-time reception sustak- represented appoint a 3 - 4 times a day. The lack of efficiency tablets sustak- represented recently was essentially (especially in the more severe forms of strokes) tablets sustak- Fort (6, 4 mg nitroglycerin), individually selecting dose and frequency reception.

     In applying sustaka tablets, as well as other drugs nitroglycerin, possible headache, lowering AD (especially in the vertical position), the feeling of heat.

     Indications are the same as for nitroglycerin.

     Product : in bottles of 25 tablets.

     Storage : List B. In a dry, cool place.

     Sustonit (Sustonit) - pill containing 2, 6; 6, 5 or 15 mg nitroglycerin. In terms of composition and of close to sustaku but inferior to the latter activity, and must be applied in large doses (1, 2, 1, 4 times).

     Produced in Poland.

     Nitrong (Nitrong) *.

     Mikrokapsulirovannaya medicinal form of nitroglycerin prolonged action in the form of tablets containing 2, or 6 6 5 mg nitroglycerin.

     A few more long-term (2 to 3 hours) than Sustak. Activity occurs during the first hour, the maximum effect through 3 - 4 hours

     Applied as Sustak, for the prevention of strokes in chronic IBS. Assign to the food inside. Pill proglatyvayut, squeezed a small amount of water. Is usually 1 - 2 pills to receive 2 to 3 times daily. The maximum single dose and no more than 2 to 6 tablets, 5 mg tablets, or 5 to 2, 6 mg; The maximum daily dose of 6 tablets of 6, 5 mg.

     Adverse events and contraindications are the same as for other drugs sustaka and nitroglycerin.

     Product : in bottles of 50 and 100 tablets.

     Storage : List B.

     Nitro Poppy ointment (Mas o-Nitr retard) *.

     Capsules containing granules mikrokapsulirovannye with nitroglycerin. Contents of nitroglycerin in a capsule of 2, 5 or 5 mg. Nitroglycerine is gradually released from the capsules and provides extended benefits (up to 8 to 12 h).

     Indications and contraindications are the same as for nitrogranulonga, sustaka, nitronga.

     Product : in bottles of 50 capsules.

     Sustabukkal (Sust and buccal) *.

     Hominids (bukkalnye) tablets, containing 0,002 or 0,005 grams (2 or 5 mg) nitroglycerin.

     Put pill in the mucous membrane of the mouth of the cheek and holding, not proglatyvaya to complete resorption. Effects manifested through 3 - 5 minutes and lasts 3 to 6 hours

     Dose picked individually, usually for one pill, containing 2 mg, 3 times a day.

     Indications and contraindications are the same as for other prolonged preparations nitroglycerin.

     Product : tablets in a package for PC cards.

     Produced in Yugoslavia.

     Ointments "Nitro" 2% (Unguentum "Nitr about 2%).

     Maze contains 1 g of 20 mg nitroglycerin (for ? application). Mazevaya basis (paraffin, tsetanol, oksipropiltsellyuloza, Petroleum jelly) intake contributes nitroglycerin skin. Ointments can be applied to different parts of the skin (often in the heart of the forearm, etc.). Dose choose individually vydavlivaya tubes of different lengths sterzhenek masi, otmerivaemoy attached line (from 0.5 to 5 cm). After causing masi, plot skin cover durable paper reinforce bandage. The effect characteristic of the nitrates action, it's usually after 30 to 40 minutes and lasts about 2 to 5 hours Maze of the nitrate-acting drugs, and usually appointed as an additional tool in combination with oral nitrate used to prevent strokes.

     Dose and Frequency of masi should be installed individually; Given the wide variations in BAS nitroglycerin ointment from different patients, as well as from the same patient depending on the ambient temperature, skin temperature and humidity, and other factors.

     Product : in tubes containing 45 grams of masi.

     Similar preparations are produced abroad under the title : "Miovin (Muo vin)," Nitrol (Unguentum "Nitrol"), "Nitrobid (Nitrobid) and others.

     Nitroderm (Nitroderm) *.

     Special transdermalnaya system-plaster containing nitroglycerin (50 mg in plaster).

     In causing the skin provides long nitroglycerin in blood flow (up to 24 g) with the largest concentration in the first 6 hours

     Antianginalnogo applied as a tool in stable and unstable angina. The nuisances in the form of application to the skin surface perednebokovoy chest (left), or skin left on 25-50 mg.

     Optimal conditions for the use (dose, frequency applications) set individually. There may be significant variations in performance (see Maze "Nitro").

     The twin actions transdermalnye system (produced) are issued as the "Nitrodur (Nitrodur"), etc.

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