RISTOMITSINA SULFAT (Ristomycini sulfas).

     Ristomitsin - antimicrobial substances produtsiruemoe Proactinomyces fructiveri var. ristomycini.

     Synonyms : Ristocetin, Spontin.

     Ristomitsina sulfate is a porous mass of powder or cream-coloured odourless. Mg in the water.

     The drug suppresses the development of micro gram (staphylococcus, streptococcal pneumococcal), listery, forbs gram sticks, and many anaerobov acid bacteria. At gram bacteria and fungi is not operating. Active against stafilomitsetinu, tetracycline, neomycin and other antibiotics.

     Drug activity is expressed in units of (ED). Theoretical activity 960 ED / mg, practical-800 ED / mg.

     When administered medication little absorbed. When intravenously quickly enters the different organs and tissues. Most of the products displayed in the urine during the first 3 h after injection.

     Applied mainly heavy septic infections caused by gram microorganisms, especially staphylococcus, resistant to the actions of other antibiotics : septic endocarditis, stop, and pnevmokokkovom streptococcal sepsis, gematogennom bullet, eight meningitis and other heavy kokkovyh infection is not curable other antibiotics.

     Ristomitsina sulfate impose only intravenously. In subcutaneous introduction has irritating effects.

     Daily intake for adults is 1000000 1500000 - ED, for children - 20000 - 30000 ED 1 kg of body weight; Give 2 reception at intervals of 12 hours

     Diluted dissolve in the 30-40 ml of sterile isotonic sodium chloride solution, or 5% glucose solution and slowly introducing vein. You can also write drip plant 250000 ED drug in 125 ml and 1 million ED-500 ml isotonic sodium chloride solution.

     At the end of infusion should not removing the needles, a 10-20 ml isotonic sodium chloride solution (for washing veins and prevent development flebita).

     This treatment is a disease. When pneumococcal and streptococcal diseases, treatment usually continues at least 5 to 7 days. In acute and subacute bacterial endocarditis caused by staphylococcus or enterokokkami, treatment is 14 to 20 days (up to 30 days), the product appoint 500000 750000 ED-2 times a day.

     Introduction ristomitsina sulfate (mostly in the early days) may be accompanied by fever and sometimes nausea. Caution should be exercised when treating patients with sepsis and anurii oligurii phenomena; To normalize the relative density of urine, drugs give small doses of 250000 ED after 48 h.

     During treatment must monitor kidney function, blood studies. For patients of possible radiation and neutropenia.

     In the case of allergic reactions protivogistaminnye using drugs. To prevent these reactions should enter dimedrol or other drugs protivogistaminnye intramuscularly for 15 - 20 minutes before the injection solution ristomitsina.

     The drug is not suitable for thrombocytopenia.

     Product : in the hermetically ukuporennyh bottles of 100000 and 500000 ED.

     Storage : List B. In the dark place at a temperature no higher than  + 20C.

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