RIFATIROIN (Rifathyroinum).

     Piroglutamil- gistidil- prolinamid (tripeptid).

     Synonyms : Tiroliberin, Hirtonin, Protirelin, Relefact TRH, Thypinone, Thyrefact, Thyroliberin, Tiregan, et al.

     White or white with a barely noticeable yellowish sheen amorphous powder. Mg in water and alcohol.

     Thyrotropin-releasing hormone (rifatiroin) is a major factor rilizing- hypothalamus. He helped to release tireotropnogo pituitary hormone, ie is rilizing- factor tireotropnogo hormone. In addition, the hormone has many effects on the body. It stimulates the secretion of prolactin, has antidepressant activity.

     The main application hormone (rifatiroin) as a diagnostic tool has various forms of hypothyroidism, as well as the gipotalamo- gipofizarnotireonoy system with different endocrine diseases; It is also employed to determine the hypophyseal reserve prolactin women with hypo and agalaktiey (no milk secretions), and endocrine disruption.

     Enter struyno single intravenous dose of 500 µ g (0.5 mg). Before the introduction and through 15; 30, and 120 min after the introduction determine contain a substance tireotropnogo hormone and prolactin in the blood.

     Since the introduction rifatiroina 1 to 2 minutes possible nausea, a feeling of warmth, dizziness, passing themselves.

     While the application rifatiroina to diagnose disabilities gipotalamo- gipofizarno- tireoidnoy system and to monitor therapy tireoidnymi drugs by intranasal rifatiroina (causing dose of 1000 ug small drop in the mucous membrane of the nose).

     In connection with psychotropic activity tiroliberina, studied the positive results of its effect on alcohol withdrawal syndrome. The drug was placed in intravenous dose of 200 ug.

     Application rifatiroina contraindicated in pregnancy.

     Product : in capsules containing 500 µ g of dry product. Before use, planting 500 µ g in 2 ml of sterile water for injection or isotonic sodium chloride solution.

     Storage : List B. In the dark place at a temperature of 4 C.

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