RIFAMITSIN SV (Rifamycin SV).

     Natural antibiotic produtsiruemy radiant fungus Streptomyces mediterranei.

     Based on the obtained semisynthetic antibiotic compounds, the most important of which is rifampicin (see), used primarily as a means of TB.

     Rifamitsin SV issued in the form of sodium salt.

     Synonyms : Rifogal, Rifotsin, Rifocin, Rifogal, Rifomycin SV et al.

     The drug has a strong anti-primarily gram of bacteria, including strains resistant to other antibiotics. Active against Mycobacteria tuberculosis. In a large concentration of coliform wand and proteus.

     Stability of microorganisms to rifamitsinu SV (and other rifamitsinam) develops quickly.

     Cross-resistance to other antibiotics, however.

     When ingestion, the drug is poorly absorbed and it just dropped. In intramuscular introduction absorbed quickly. Little crosses the blood-brain barrier.

     Provided mainly with bile and small amounts of urine.

     Applied infection in the skin and soft tissue caused by staphylococcus and other gram coccus, for the treatment of pneumonia, broncho, abscesses and light empiemy pleura, stop sepsis, enterocolitis, osteomyelitides cholecystites, holangitov. Oseltamivir appointed to the operation of biliary tract.

     Applied intramuscularly and intravenously, as well as local.

     Intramuscularly introduce adults and children who weighed more than 25 kg (over six years), to 0.25 g (250 mg) 2 - 3 times a day at intervals of 12 or 8 hours Children under the age of six years are designated 10-30 mg / kg per day.

     Intravenous (slowly) to introduce adults to 0.5 to 1, 5 grams (1 to 3 mg 500 mg) a day, the children - 10-30 mg / kg per day. Daily dose divided into 2 to 4 of the same intervals. The drug can be administered by intravenous drip (in isotonic sodium chloride solution, or 5% glucose solution).

     For local applications in the treatment of ulcers, fistulas (for washing, soak tampons), to throw out the contents of one vial (125 mg) in 25 mL of sterile distilled water; When empiemah 125-250 mg to throw in 2 ml of sterile water for injection, for the introduction of bronchi - 125 mg of 2 - 3 ml of sterile water for injection 1 every 2 days. Rifamitsin rarely cause allergic reactions (skin deterioration, eosinophilia), quickly disappearing after preparation.

     In the long intravenously may tromboflebitov development.

     Caution should be observed in the appointment rifamitsina patients with violations of liver function (available jaundice).

     Injecting drug use contraindicated violations as expressed in the liver. Nor should designate product in the first three months of pregnancy.

     Product : in ampoules of 1, 5 and 3 ml, containing, respectively, 125 and 250 mg preparation (for intramuscular and local applications); In 10 ml ampoules containing 500 ml of intravenous drugs).

     Storage : List B.

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