RIFABUTIN (Rifabutin).

     11.4-Didegidro-1- dezoksi-1, 4-dihydro-5? - (2-metilpropil) -1 - oksorifamitsin XIV.

     Synonyms : Mikobutin, R Boutin, Mycobutin.

     Red-purple powder. Almost nerastvorim water poorly soluble in ethanol is soluble in chloroform and methanol.

     Semi antibiotic. There are different types of mycobacteria, including tuberculosis micobacterium.

     Quickly and completely absorbed in the digestive tract, A max is 2-4 h, T? 35-40 h; well prinikaet authorities and textile (the highest concentration of a light); being biotransformation in the liver out with the urine and bile.

     Applied as a backup TB drug. Used also for the generality of infection by M. avium-intracellulare complex, in HIV-positive patients.

     Assign inside (in food) for adults with tuberculosis 0,15-0,3 grams a day in one reception (with a bad portability of 0.15 g 2 times daily), with netuberkuleznyh infection on 0,45-0, 6 grams a day.

     Possible side effects : nausea, vomiting, bronchospasm, disruption of the liver, jaundice, thrombocytopenia, radiation, anemia, skin rashes, fever.

     The drug is contraindicated in pregnancy, breast-feeding, at age 14.

     Product : Capsule to 0.15 g (N. 15).

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