Riboksin (riboxinum)


RIBOKSIN (Riboxinum). 9-b -D- Ribofuranozilgipoksantin or gipoksantin- ribozid.
     Synonyms : Inozie-F, Inozin, Atorel, Inosie-F, Inosin, Inosiron-E, Inotin, Irpelen, Oxiamin, Ribonosine, Teberin, Trophicardyl and others.
     White or white with a yellowish sheen weak crystalline powder, bitter taste, and odourless. Slow and difficult to dissolve in water, very little is soluble in alcohol.
     Riboksin is derived (nukleozidom) Purina. It can be viewed as a predecessor ATF. There is evidence of the ability of drugs to enhance the activity of some enzymes Krebs cycle, stimulate the synthesis of nucleotides, have positive effects on the metabolic processes in the attack and improve coronary circulation. By type of action related to anabolic substances. As nukleozidom, inozin can penetrate into cells and increase energy balance attack.
     Riboksin applied to the treatment of coronary heart disease, myocardial infarction forward, myocardiodystrophy, rhythm irregularities involving the use of cardiac glycosides. Assign well as liver diseases (hepatitis, cirrhosis), and for the treatment urokoproporfirii. There is also an improvement by riboksina visual function in patients with glaucoma (otkrytougolnaya form with an under the influence of anti-hypertensive therapy inner pressure). The effect apparently associated with antihypoxic of preparation.
     Is riboksin inside to food in the daily intake of 0.6 to 2, 4 d. In the first days of taking on the 0.6 - 0.8 g / day (0.2 g for 3 to 4 times a day), with good endurance increase the dose within 2 to 3 days of 1, 2 grams a day (0.4 g three times) to 2, 4 grams a day.
     The course of treatment lasts four weeks to 1, 5 to 3 months. In urakoproporfirii riboksin take in a daily dose of 0.8 g (0.2 g for 4 times) daily for 1 3 months.
     Applied also riboksin intravenously. Enter struyno slow drip (40-60 drops per minute). Beginning with the treatment of 200 mg (10 mL of 2% solution) 1 times a day, then, with good endurance, increase the dose to 400 mg (20 mL of 2% solution) 1 to 2 times a day. The duration of treatment of 10 to 15 days.
     In severe violations of heart rhythm and conduction may inkjet products in a single dose of 200 to 400 mg (10 to 20 mL of 2% solution).
     To grow a drip solution riboksina in isotonic sodium chloride solution, or 5% glucose solution to 250 ml.
     The drug is usually well; In some cases, may itch, hyperemia skin; In these cases, medication overturned. In rare cases, there is an increased concentration of uric acid in the blood. With long-term use of high doses may increase gout.
     Method of production : tablets, coated (yellow) to 0.2 g (T abulettae Riboxini 0.2 on bductae) in a package of 50 pieces; 2% solution in 10 mL ampoules.
     Storage : List B. pills and capsules at room temperature in the dark places.

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