RIBONUKLEAZA (amorphous) (Ribonucleasum amorphum).

     Enzyme preparation obtained from the pancreas of cattle.

     Dried powder white or white with a cream-coloured shade. The easily soluble in water, isotonic sodium chloride solution, the solution novocaine.

     Ribonuclease has specific RNA depolimerizovat ability to kislotorastvorimyh mono and oligonucleotides. The drug can dilute Pus, narrow, thick and viscous sputum; Also anti properties.

     Because of the nucleic acid, ribonuclease has the ability to delay reproduction of RNA containing viruses.

     Ribonuclease determine biological activity by the number kislotorastvorimyh substances released by hydrolysis product ribonucleic acid opredelenyh conditions. One unit of activity (EA) with 1 mg drug.

     Key testimony to the use of ribonuclease, possible complications and contraindications and precautions are the same as for crystalline trypsin. In addition, drug use (intramuscularly) for the treatment of tick-borne encephalitis (with severe forms of the disease combined with gamma protivoentsefalitnym globulinom). There are performance ribonuclease amorphous with viral meningitis.

     Applied locally, in the form of aerosols for inhalation, vnutriplevralno, intramuscularly. When local application prisypayut wound or ulcer powder surface preparation in the number of 0,025 - 0,05 g (25-50 mg) and employ napkins or tampons, soaked in the solution preparation isotonic sodium chloride solution.

     To enjoy dispersible aerosol inhalation; 25-mg dose of the procedure; Drug dissolve in 3 - 4 ml isotonic sodium chloride solution, or 0.5% solution of novocaine. Endobronhialno enter through guttural syringe or catheter solution containing 25-50 mg drug. Vnutriplevralno impose the same dose of 5 to 10 ml isotonic sodium chloride solution, or 0.25% solution of novocaine.

     When sinusitis give verhnechelyustnuyu (gaymorovu) doctor (after piercing and washing) 5 - 10 mg of 3 - 5 ml isotonic sodium chloride solution; When otites buried 0.1% solution (0.5 mL - 1) in the ear.

     Intramuscularly introduce 5 - 10 mg in 1 ml isotonic sodium chloride solution, or 0.5% solution of novocaine. In the course of 2-10 injection of 1 - 2 injections a day. The maximum single dose of 10 mg intramuscular injections in the local and intraoral a 50 mg.

     For treatment of tick-borne encephalitis impose intramuscularly. Occasional doses for children up to 1 year 3 mg, 2 to 3 years, 5 to 8 mg (depending on body weight), 4 to 6 years, 10 - 14 mg, from 7 to 11 years, 15 to 18 mg, 12 20 to 15 mg, for adults 25 to 30 mg. Repeat injections six times a day with a 4-hour intervals. Number of drug injections to dissolve in 2 ml of 0.25 - 0.5% solution of novocaine.

     Prior to treatment samples sensitivity to the drug : in sgibatelnuyu surface of the forearm impose intracutaneously 0.1 ml. In the absence of local and general reactions to the drug treatment. Introduction drug cease once during the two day patient, a normal body temperature.

     Product : in the hermetically ukuporennyh vials or ampoules and 10; 25 and 50 mg.

     Storage : dry, the dark place at a temperature of not more than 15 'C.

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