REUMITSIN (Reumycinum).

     Antitumor compounds extracted from ksantotritsina, produtsiruemogo As tinomyces rectus bruneus subsp. xanthothricini. 6, 8-methyl Digidro-6- pirimido [5, 6 th] - 1, 2, 4-triazine - 5, 7-dione.

     The yellow crystalline powder. Slowly and poorly soluble in water. Sensitive to the action of light.

     It has antitumor activity, mainly in malignant tumors (gliomy etc.) brain. Applied usually after surgical removal of tumors in the absence of postoperative complications. Treatment begun by 7 to 8 days after the operation.

     Injectable Solution prepared immediately before use. Enter endolyumbalno and (or) intravenously. For endolyumbalnogo dissolve the contents of a bottle-0.02 g (20 mg) in 10 ml isotonic sodium chloride solution, intravenous add to the contents of a bottle-0,01 g (100 mg), 200 ml isotonic sodium chloride solution, or 5% solution glucose.

     Beginning with the introduction endolyumbalnogo 2, 5 mg or 100 mg intravenously. With good endurance gradually increase the dose to 5 - 10-200 mg or 300 mg respectively.

     Endolyumbalnye of produce every 48 h to a total dose of 0.05 g (50 mg). In non impose daily for a period of 10 to 12 days to a total dose of 1 to 2 grams.

     Repeated courses conducted at 2 - 2, 5 months.

     Reumitsin can be used alone or in combination with other means and methods of treating brain tumors.

     In applying reumitsina may be nausea, vomiting, headache, increased body temperature. When intravenously EKG changes can be observed in such cases reduce the dose or stop the introduction of the drug.

     Contraindications to the use reumitsina are expressed arterial hypertension, severe heart disease, kidney, liver, diabetes, inflammatory postoperative complications, prone to allergic reactions.

     Product : a mass of yellow on the 0.02 g (20 mg) in 10 ml vials of capacity and 0.1 g (100 mg) in 25 ml vials of capacity in a package of 20; 40 and 50 bottles.

     Storage : List A. In the dark place at a temperature no higher than +10  C.

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