REPAGLINID (Repaglinide).

     (+) -2 - Etoksi- ?-[[( S)? ortho-izobutil- piperidino- benzyl] karbamoil] parameters toluilovaya acid.

     Synonym : NovoNorm, NovoNorm.

     By blocking ATP dependent potassium channels? - Pancreas cells, causes them depolarization, resulting in the opening of calcium channels and, consequently, increased insulin secretions.

     Quickly and completely absorbed in the digestive tract, bioavailability of approximately 56%, with max-1 h, T? 1-h; under intense biotransformation in the liver, bile appears mainly.

     Applied diabetes type II.

     Assign inside (to receive food), from 0.0005 g (0.5 mg) three times a day, increasing the dose, depending on glycemia at least 1-2 weeks. The maximum single and daily doses up to 0,004 and 0,016 grams (4 and 16 mg). You can combine with metformin.

     Possible side effects : gipoglikemicheskie reaction, neuralgia, the severity of the violation.

     The drug is contraindicated in diabetic coma expressed violations liver and kidney functions, pregnancy and breastfeeding.

     Product : pills to 0.0005; 0,001 and 0,002 grams (0.5; 1 and 2 mg) (N. 15, 30).

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