HINAPRIL (Quinapril).

     Ethyl ether 2-[N-[1-karboksi-3- fenilpropil] - alanil] -1,2,3,4 - tetragidro-3- izohinolinkarbonovoy hydrochloride acid.

     Synonyms: Akkupro, Kvinapril, Accupro.

     White or not white amorphous powder. Soluble in water.

     Alaninsoderzhaschy inhibitor APF (no sulfgidrilnyh groups).

     In ZHKT absorbed about 40% of dose, C max of 1 h, T? 3-h; appears unchanged from the urine and bile.

     Apply with arterial hypertension and congestive heart failure.

     There is a positive experience hinaprila use in acute heart attack during Chavez (was a decrease in the number of patients with signs of heart failure, frequency and extent progressing dilatatsii left ventricle, increasing fraction of the emission, etc.).

     Assign inside.

     When arterial hypertension initial dose of 0.01 g (10 mg) 1 hour per day (in combination with diuretikami and kidney functions violations 2.5 mg / day). If necessary, gradually increase the dose to 0,02-0,04 g (20 -40 mg) a day (in the 1-2 receiving). The maximum daily dose of 0.08 g (80 mg).

     There is evidence that the effectiveness antigipertenzivnoy hanipril than lizinopril, amlodipine and gidrohlortiazid and is comparable atenolu.

     In congestive heart failure initial dose of 0.0025 g (2.5 mg), supporting-0,01-0,02 g (1-2 in the reception), the maximum is 0.04 g (40 mg) a day.

     Possible side effects and contraindications essentially the same as that of the amlodipine and Captopril.

     Method of production: tablets to 0,005; 0.01 and 0.02 g (5, 10 and 20 mg) (N. 10, 30, 50).

     Storage: List B.

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