PIROMEKAIN (Pyromecainum). 2, 4, 6-butyl - Trimetilanilid-1- pirrolidinkarbonovoy-2- hydrochloride acid, or 1-butyl - 2, 4, 6-trimethyl pirrolidinkarboksanilid.

     Synonyms : Bumecain hydrochlorid, Bumecaini hydrochloridum, Pirromecain.

     White or white with poor cream flavor crystalline powder. Mg in the water, easy-to alcohol. The solutions (pH 2% solution of 4, 4, 5, 4) prepare for isotonic sodium chloride solution, sterilized with 100 'C for 30 min.

     Mestnoanesteziruyuschee funds. On chemical structure is similar to trimekainom. Has also antiaritmicheskoe effect.

     As usual means used for the surface anesthesia.

     In practical use in ophthalmic solution 0.5% for 1 - 2 drops; In practice otorinolaringologicheskoy-1 - 1-5 mL 2% solution (if necessary add 0.1% epinephrine hydrochloride solution to one drop every 2 to 3 ml piromekaina) ; for pain in endoscopic research-2 - 5 mL 2% solution; dental-1 - 1-5 mL of 2% or 5% solution piromekainovuyu ointment.

     As antiaritmicheskogo means piromekain appointed in zheludochkovyh adults : with heart attacks, cardiac glycosides intoxication, etc. Enter piromekain intravenously in a 1% solution of 5% glucose solution struyno slowly at the rate of 1 ml / min in 50-dose 100 mg (5 - 10 ml of 1% solution) for 3 to 5 minutes. For long-term therapy piromekain injected struyno slowly at the rate of 1 mL / min dose of 100 mg (10 ml) 2 - 3 times with an interval between the introduction of 15 - 20 minutes. Achieved protivoaritmichesky supported drip effect of the drug at a speed of 2 to 3 mg / min (8 - 12 drops per minute). In acute myocardial infarct piromekain enter : 1) dose of 100-150 mg (10 - 15 ml of 1% solution) intravenously struyno slowly for 3 to 5 minutes (one bolyus); 2) in the dose of 100 mg (10 mL 1% solution ) 2 times with a 15-spaced 20 minutes against the backdrop of a drip-bolyus twice in the face Infusion.

     Infusion duration depends on the nature of and during the process and effectiveness of therapies.

     The average single intravenous dose of 1% solution of 0.1 g (100 mg).

     The highest daily intake, with the introduction of non-1, 5 grams (1,500 mg).

     In applying piromekaina possible weakness, nausea, vomiting, dizziness, falling blood pressure, kollaptoidnoe state. If necessary, recommended sosudosuzhivayuschie funds. Intravenous introduction should take place only in the United States.

     Method of production : 0.5%; 1% and 2% of injectable solutions to 10 ml, 1% solution in 5% glucose solution for intravenous (Sol. Ru r mecaini about 1% cum glucoso pro injectionibus) in 10 ml ampoules; 5% piromekainovaya ointment.

     Storage : List B.

     Ointments piromekainovaya 5% (Unguentum Pyromecaini 5%). Applied as anaesthetic in inflammatory diseases mucous membranes of the oral cavity. Apply a thin layer to the painful area on one or oven for 2 to 5 minutes. Masi dose should not exceed 1 year

     Product : in the box for 1930

     For use in dental practice is also designed ointment (gel), containing 100 g and 5 g piromekaina metiluratsila 5 g. Metiluratsil promotes antitussive and repairing processes. Assign aftoznom for acute disease, yazvenno- necrotic gingivitostomatite and others.

Materials allowed to copy only with the active hyperlink to the handbook of medicines