PIRIDITOL (Pyriditolum).

      Bis (2-methyl oksi-4- oksimetilpiridil-5- methyl) - disulphide digidrohlorid.

      Synonyms : Piritinol, Enerbol, Entsefabol, Biocephalin, Bonifen, Cefalogen, Cervitalin, Cogitan, Dipiridol, Enbol, Encerebrovit, Encefabol, Encefort, Encephabol, Enerbol, Estisol, Neurotin, Neuroxin, Piritinol, Psicobolin, Pyrithioxin, Pyritinol, Tonobrein and others.

      White or white to slightly yellowish sheen crystalline powder. The easily soluble in water, soluble in alcohol little.

      The structure differs from Pyritinol neuroprotective drugs GAMKergicheskoy nature. It can be seen as a double molecule pyridoxine (see) containing disulfidny <> (<bridge> disulphide pyridoxine).

      Pharmacologically product is nootropnoy activity with a complex array of psychotropic activity. It reinforces fenamina effects, however, reduces the spontaneous locomotor activity, to prolong sleeping pills, barbiturates, strengthens protivosudorozhnoe of phenobarbital. The drug activates metabolic processes in the central nervous system, helping to accelerate the penetration of glucose through the blood-brain barrier, reducing excess education lactic acid, increases resistance to brain tissue hypoxia. There is a decline by piriditola of GABA in nerve tissue. At 6-vitamin A activity is not.

      In clinical effects Pyritinol similar to antidepressants with sedatives properties, but coupled his classified as neuroprotective drugs.

 

      Pyritinol using adjuvant therapy with shallow depression with events sunk in meningitic state, adinamii, drew disorder, with traumatic and vascular encephalopathy, residual problems after an neyroinfektsy and disturbance of cerebral circulation, with cerebral arteriosclerosis, and migraines. The children used to delay mental development, tserebrastenicheskom syndrome, mental retardation, encephalopathy.

      Is Pyritinol inwards (within 15 to 30 minutes after eating) 2 - 3 times a day. Under the adult dose 0.1 - 0.3 g; Child-0.05-0.1 g; Daily intake for adults of 0.2 to 0.6 g (typically 0.3 - 0.4 g) Childhood 0.05 - 0.3 in the first 10 days of preparation appoint a lesser dose (adults 0.3 - 0.4 g / day), and then, if necessary, and good endurance dose increase. The course of treatment is continuing in adults 1 - 3-(6 - 8 months), children from 2 weeks to 3 months. Repeated treatments for adults after 6 months-1 break, the children after 3 to 6 months.

      In applying piriditola possible headache, nausea, insomnia, irritability, in children, psychomotor institute, sleeping. In these cases, reduce the dose. The drug is not recommended to take in the evening hours.

      Contraindicated in psychomotor expressed anxiety, epilepsy, high-convulsant preparedness.

      Method of production : tablets of 0.05; 0.1 and 0.2 g-coated yellow, in a package of 60 pieces.

      Storage : in the dark, dry place. 3 and overseas entsefabol is also in the form of pills and 0.1 grams of syrup containing 0.1 grams for each 5 ml (teaspoonful), in bottles of 200 ml. Herbal nominate children for 1 / 2 to 1 teaspoonful of 1 to 3 times a day (depending on age).

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