PROTAMINA SULFAT (Protamini sulfas).

     Diluted protein origin, derived from the sperm of different species of fish. Contains arginine, proline, serine, Alanine and other amino acids. For medical purposes apply mainly protamine (Salmeen), derived from salmon sperm.

     The drug has a peculiar effect protivogemorragicheskoe with bleeding caused by incidents. Effective from certain types gemorragy of geparinopodobnymi violations blood clotting.

     Protamine sulfate applied mainly to neutralize excess exogenous unchanged : it overdose after operations using extracorporeal circulation and the use of heparin and others.

     Available in a 1% solution for injection (Solutio Protamini sulfatis 1% p ro injectionibus) is a transparent colorless liquid; PH 4, 0, 6, 0.

     Activity drug determine biological method for neutralizing capacity protivosvertyvayuschee of incidents at the sheep or bovine plasma in vitro, in the presence of excess calcium chloride. Activity is expressed in units of action (ED). In 1 ml 1% solution should contain at least 750 ED; 1 mg neutralizes approximately 85 ED unchanged.

     Enter Protamine sulfate solution struyno intravenous drip controlled blood coagulability.

     Struyno impose slowly at the rate of 1 ml of 1% solution for 2 minutes. If Protamine sulfate impose no later than 15 minutes after the incidents, is to neutralize 100 ED incidents required 0.1 - 0.12 ml of 1% solution Protamine sulfate. In between a large dose Protamine sulfate can be reduced. If necessary injections Protamine sulfate repeated at intervals of 15 to 30 minutes; The total dose is usually 5 ml 1% solution. In gipergeparinemii associated with extracorporeal circulation, Protamine sulfate dose can be increased; While introducing the solution drip.

     Entering Protamine sulfate solution possible allergic reactions (type urticaria); In these cases, antisense funds.

     In rare cases, and idiopathic congenital gipergeparinemii when a Protamine sulfate, there may be a "paradoxical effect - increased bleeding.

     Protamine sulfate is not suitable for sharply hypotension, thrombocytopenia, the lack of adrenal cortex.

     Product : 1% solution in vials neutral on the glass or 5 ml ampoules of 2 and 5 ml.

     Storage : at a temperature of not less than + 4 'C. Freezing is not allowed.

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