PROSTENON (Prostenonum).

     Domestic drug prostaglandina E-2-prostenon used in medical practice as alcohol (0.1% and 0.5%) solution.

     Prostenon like dinoprostu and dinoprostonu is stimulating uterine musculature and is used for generic rodovozbuzhdeniya and stimulation activities.

     Moreover, like other drugs prostaglandina E 2 (see Prostaglandiny) prostenon has hypotensive effect. Hypotensive effects associated with peripheral vazodilatatornoy activity. The product expands Venule split and increased the renal circulation, increases diureza and natriyureza has antiagregatsionnoe influence; Also has bronhorasshiryayuschey activity.

     In connection with the hypotensive action prostenon also found use for the treatment of hypertension.

     As a means to promote generic activities prostenon used in a hospital under the following conditions: a late abortion, perenoshennoy pregnancy RHESUS conflict, and in other cases, requiring early raise generic activities, including involving hypertensive disease, cardiac failure, diabetics, bronchial asthma, and premature izlitii amniotic waters, the weakness of the generic, if not contraindicated in the state of the fetus and the mother (see Contraindications).

     For use as a means to promote generic activities razvodyat 1 mL of 0.1% (or 0.5%) solution prostenona in isotonic sodium chloride solution. This content 1 ampoule mix with 500 ml isotonic sodium chloride solution, vzbaltyvayut. The resulting solution Best to use in 24 hours

     Prepared solution products are introduced at a speed of 6 to 10 drops per minute. In the absence of express effect after 20 to 30 min infusion speed gradually increase to 20 drops per minute (adds every 10 minutes for 4 - 5 drops per minute) to establish a regular generic activities. The maximum speed of the drug should not exceed 35 drops per minute. In the process of preparation to monitor the dynamic nature of descent and the fetus. Latent period ranging from 20 to 40 minutes. If gipertonusa uterus or deterioration of the fruit infusions stop solution to the disappearance of these phenomena. Infusion solution prostenona resume; Reducing the double dose; A further speed can be gradually improved. Dosage prostenona must be individual, depending on the activity of the uterus and portability. Number spent drugs ranging from 0.75 to 5 mg.

     As antigipertenzivnogo means prostenon apply in the cases that are resistant to the action <conventional> antigipertenzivnyh funds. Prostenon seen as a reserve hypotensive drugs. Apply in hypertensive disease B II and III stage glomerulonefrite chronic and persistent incidence, of ongoing with malignant arterial hypertension refrakternoy to hypotensive combination therapy, where amidst maximum doses of drugs AD consistently over 170/110 mm Art. Art.

     Treatment usually prostenonom hold in the face of continuing antigipertenzivnyh means to overcome resistance to these drugs and their hypotensive action.

     Prolonged hypotensive effect is achieved only in patients with preserved kidney function azotovydelitelnoy. Prostenon can also designate for kupirovaniya PNDS crises.

     When hypertension razvodyat normally 0.3 ml of 0.5% solution or 1, 5 ml of 0.1% solution (1, 5 mg drug) in 500 mL of 5% glucose solution and isotonic sodium chloride solution. Solution are prepared to impose a speed of 10 to 20 drops per minute. Every 10 minutes a speed of up to 4 to 8 drops per minute, bringing its 32-to 48 drops per minute. Speed limited picked individually, taking into account the hypotensive effect and feeling sick, seeking a gradual reduction in the average AD 25-40 mm Art. Art. When expressed fever, nausea, severe headache, as well as reducing the average AD more than 25 40-mm Art. Art. limited speed should be reduced to 10 to 24 drops per minute. If these feelings will not disappear, Budget should stop. Number of drug spent on legitimate one, from 0.85 to 1, 5 mg. The course of treatment 2 - 3 limited by the day or at intervals of 1 to 2 days. After treatment prostenonom daily dose of antigipertenzivnyh funds can be reduced.

     There are also data on prostenona a 3 - 5 Infusion: 1 mg product (1 ml of 0.1% solution) razvodyat 200 ml isotonic sodium chloride solution. Budget starting from 16 to 18 drops per minute, and then regulate the speed of introduction, depending on the effect (to reduce AD no more than 25 to 30% of original). The course of treatment consists of 3 - 5 Infusion intervals between 1 st, 2 nd and the third limited one day, and between the third, 4 th and 5 th limited 2 - 3 days. The total dose prostenona course is 3 to 5 mg.

     For kupirovaniya giperkineticheskih PNDS crises 1 ml of 0.5% solution prostenona razvodyat in 500 ml isotonic sodium chloride solution and impose a speed of 38-75 drops per minute. As a means opiate hypertensive crises, prostenon has no apparent advantage over intravenous solution imposed klofelina and peripheral vazodilatatorov.

     Prostenon also use the integrated treatment of acute renal failure (to restore diureza).

     In applying prostenona can develop sinusovaya tachycardia, chills, blood person, headache, drowsiness, nausea, rumbling in the stomach, female-heavy bottom abdomen. In these cases, should reduce speed limited. Can local response in the form flebita. After 3 to 4 h after the acute temperature may increase to 37-37, 5, but over the next 2 to 3 h, it falls to normal. After 20 to 30 minutes after the Budget may be single liquid stools, and the overdose and the rapid introduction of solution-vomiting.

     When excessive lowering AD should cease immediately prostenona limited. In developing resistant hypotension impose mezaton vazopressornoe or other means under the control of AD.

     If development anafilakticheskoy prostenona a response to a cease and therapy.

     Contraindications: allergy to the drug, postoperative scarring and uterine tumors, bleeding tendency to breeding, deskvamatsin phase (or predmenstruatsii) breeding cycle, a severe inflammatory disease etiology and localization (except acute renal failure), physiotherapists veins limbs and small pelvis, circulatory insufficiency II B phase-III, severe IBS, manifested attacks stenocardia voltage and tranquillity (functional class IV), a severe heart attack miokarda. Furthermore, the stimulation of birth, prostenon not appoint women to style or functionally narrow pelvis, hydrocephalus in fruit development abnormalities of the reproductive organs. As a means of hypotensive prostenon not apply to pregnant before the delivery.

     It appoint prostenon with shocked and strongly hypotension, urinary tract disease with mechanical urinary tract.

     Form release: 0.1% or 0.5% alcohol solution (1 or 5 mg) in 1 ml ampoule.

     Storage: List B. In sheltered from the world scene with a temperature of not more than 4 + C.

Materials allowed to copy only with the active hyperlink to the handbook of medicines