PROMEDOL (Promedolum). 1, 2, 5-Trimetil-4- propioniloksi-4- fenilpiperidina hydrochloride.

     Synonyms: Trimeperidini hydrochloridum, Trimeperidine hydrochloride, Trimeperidin.

     The white crystalline powder. Easy soluble in water, soluble in alcohol. Aqueous solutions (pH 4, 5-6, 0) + 100 to sterilize C for 30 min.

     Promedol is a synthetic derivative fenilpiperidina and chemical structure can be considered as analogous fenil-N- metilpiperidinovoy of morphine molecules.

     Promedol has strong analgeziruyuschey activity. He quickly absorbed and acts as the reception inside, and when parenteral introduction.

     According to influence TSNS promedol close to morphine; It reduces the perception of pain impulses TSNS, oppressing conditional though. Like other analgetikam reduces summatsionnuyu ability TSNS increases fast action Novocaine and other local anaesthetics. Provides widespread effects (primarily related to the withdrawal of pain syndrome). Compared with morphine less oppressing respiratory center, brings less selective nerve center and emetic center. 0 shows a moderate effect on the skin smooth musculature internal organs, but adds tone and makes reduce uterine musculature.

     Apply promedol pain as a means of various injuries and illnesses involving pain feelings, in preparation for the operation and postoperative period, etc. It is effective in stomach ulcer disease and stomach cancer, stenocardia, heart attack osteoporosis, intestinal, liver and renal colic, diskineticheskih zaporah and other diseases where pain syndrome associated with Muscle cramps smooth internal organs and blood vessels.

     In obstetric practice used for pain and accelerate delivery; In normal doses promedol not have collateral effects on the body of mother and fetus.

     Assign under the skin and inside intramuscularly. When parenteral use pain more pronounced effect. If necessary, enter in the veins.

     Inside assign adults to pick up on the 0,025 - 0.05 g under the skin on 1 ml of 1% or 2% of the solution, with powerful pain, especially in patients with malignant tumors, with severe trauma, etc., to enter 1 2 mL 2% solution.

     Children older than 2 years promedol appoint 0,003 - 0.01 grams per reception (inside and injections), depending on age; For children under 2 years do not apply the product.

     Effects promedola is 10 to 20 minutes and usually after a single dose during 3 to 4 hours or more.

     When the pain associated with cramps smooth musculature (stenocardia, liver, kidney, coliform colic, etc.), can appoint promedol with holinoliticheskimi and spazmoliticheskimi means: atropine, metatsinom, papaverinom and others.

     There are promedolom anesteziologicheskoy in practice. It is an essential component of apoptosis. To enter sedation under the skin or intramuscularly 0,02 - 0,03 g (1 - 1 5 mL 2% solution), together with 0.0005 g (0.5 mg) atropine 30-45 minutes before the surgery. For emergency sedation drugs give veins. During anaesthesia promedol used as a means protivoshokovogo fractional dose intravenously for 3 - 5 - 10 mg. Introduction promedola slightly deepening anaesthesia increases analgeziyu that reduces tachycardia and normalizing blood pressure. Promedol can be used together with neyrolepticheskimi, antihistamines drugs holinolitikami in general and local anesthesia. Combined with droperidolom or other brain promedol using central analgezii.

     In the postoperative period promedol apply (in the absence of a violation of breath) for the withdrawal and as a means protivoshokovoe. Enter under the skin 1 ml of 1% or 2% solution alone or in combination with dimedrolom (see).

     Promedol suitable for use in anaesthesiology, because it oppresses relatively weak breathing. Lack he spazmogennogo impact on the smooth musculature and sphincter (and even the existence of the skin) reduces the possibility of delay urination and bowel gas in the postoperative period.

     For the pain of childbirth promedol enter the skin on 1 - 2 mL of 2% solution in disclosing vigorously for 1, 2, 5-toe with good fruit (in the normal heart rhythm and frequency reductions); If necessary, repeat injections after 2 - 3 hours.

     Higher doses for adults inside: off 0.05 g daily 0.2; Under the Skin: single 0.04 g, 0.16 daily d.

     Promedol generally well tolerated by. In rare cases, there may be slight nausea, sometimes dizziness, weakness, the feeling of light intoxication.

     These phenomena are alone. If there are side effects with repeated use of the drug, the dosage should be reduced.

     In applying promedola may develop habit (reducing agent) and painful addiction.

     Promedol contraindications to the oppression of breath.

     Method of production: tablets to 0,025 g; 1% and 2% solutions in the ampoule and syringe tyubikah to 1 ml.

     Storage: A. In a list ukuporennoy packaging. Allow it to fall to the same restrictions as other drugs analgetiki.

Materials allowed to copy only with the active hyperlink to the handbook of medicines