PROGESTERON (Progesteronum).

     Pregnen-4- dione-3, 20.

     Synonyms : Agolutin, Akrolutin, Gestone, Glanducorpin, Gynlutin, Lipolutin, Lucorten, Luteine, Luteogan, Luteopur, Luteostab, Luteosterone, Lutocyclin, Lutoform, Lutogyl, Lutren, Lutromon, Lutrone, Progelan, Progesteroid, Progesterone, Progestin, Proluton, and Syngestrone etc.

     The white crystalline powder. Almost nerastvorim in water, soluble in alcohol, it is difficult to dissolve in vegetable oils.

     Is hormone yellow body. For medical use are synthetic means. Received a number of synthetic drugs that are close in structure to progesterone (see Pregnin, Noretisteron, etc.) and are active progestin, ie substances that have progesteropopodobnoy activity.

     Endogenous progesterone causes mucous membranes of the uterus phase proliferation caused Acne hormone, in the secretion phase, and after fertilization helped her in a state of transition that is required for the fertilized eggs. It also reduces anxiety and sokratimost uterine musculature and tubal, stimulates the end of breast.

     A similar effect has synthetic progesterone and its analogs in their use as medicines.

     Progesterone appointed with amenorrhea, anovulyatornyh uterine krovotecheniyah, infertility, pregnancy nedonashivanii, algodismenoree motivated gipogenitalizma. Enter in the form of oil solutions subcutaneously or intramuscularly.

     In krovotecheniyah of ovarian dysfunction appoint 0,005 - 0,015 grams (5-15 mg) daily for 6-8 days. If you made Loayza mucosal uterine cavity, starting injections after 18 to 20 days. If a Loayza impossible to impose progesterone and during bleeding. When using progesterone during bleeding, it may temporarily (for 3 - 5 days) increase; Sharp anemizirovannym patients are encouraged to make blood transfusions (200-250 ml). In ostanovivshemsya bleeding should not interrupt treatment for six days earlier. If the bleeding has not stopped after 6 to 8 days of treatment, the continued introduction of progesterone inappropriate.

     In gipogenitalizme amenorrhea and treatment beginning with the appointment of oestrogen drugs to raise sufficient proliferation endometrium. Immediately after the application of oestrogen drugs designate progesterone in the form of injections to 5 mg daily or 10 mg every other day for 6 to 8 days (see Estron).

     In algodismenoree (dismenoree) progesterone often reduces or eliminates the pain. Treatment beginning for 6 to 8 days before menstruation. Diluted imposed daily 5 or 10 mg for 6 to 8 days. The course of treatment can be repeated several times. Progesterone Treatment algodismenorei of underdeveloped uterus, can be combined with the appointment of oestrogen drugs. Estrogen imposed at the rate of 10,000 a day in the ED for 2-3 weeks; Then during the six days entering progesterone.

     For the prevention and treatment of threatening and the fetus beginning of the lack of functions yellow body, take 10-25 mg progesterone every day or two to complete disappearance of symptoms of a possible miscarriage. When abortion was given medication to impose IV months pregnant.

     The drug is usually well. Possible side effects : increased blood pressure, swelling.

     Contraindications : violation of the functions of liver, hepatitis, breast cancer and genital organs, the propensity to brain.

     Higher-time and daily intake for adults intramuscularly 0,025 grams (2.5 ml of 1% solution of 1 or 2 ml, 5% solution).

     Product : 1% and 2.5% solutions (10 and 25 mg) in oil in capsules to 1 ml.

     Storage : List B. In the dark spot.

     Rp. : Sol. Progesteroni oleosae 1% 1 ml

     D. t. d. N 10 in ampull.

     S. At 1 ml intramuscularly

     Progesteronopodobnogo of medicines used to treat prostate gland adenoma (see Gestonoronkapronat).

     Gestageny (progestin) are blocking effect on the secretion of factors gipotalamicheskih release lyuoteiniziruyuschego and follikulostimuliruyuschego hormones, dismal education pituitary hormones gonadotropnyh and impeding ovulation. Several synthetic progestinov used this as a major part of oral contraceptives (see).

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