PRIMAHIN (Primachinum). 8 - (4-methyl Amino-1- butilamino) -6 - metoksihinolin.

     Issued in the form diphosphate.

     Synonyms: Avlon, Neo-Quipenyl, Primaquine diphosphate, Primaquini diphosphas.

     Melkokristallichesky powder bright yellow, bitter taste. Soluble in water.

     Provides antiprotozoynoe effect on the sexual forms, and shizonty paraeritrotsitarnye plazmoidov all forms of malaria.

     Apply to prevent relapse in the remote three-and four tropical malaria. Also nominated for personal chemoprophylaxis in combination with hingaminom (chloroquine), as well as public chemoprophylaxis.

     Accepted inside. Daily dose for adults 0,027 g (27 mg) primahina diphosphate, ie three tablets of 0,009 grams, which corresponds to a daily dose of 0,015 primahina g (15 mg). The course of treatment 14 days.

     Daily dose for children under 1 year-0.00225 grams (1 / 4 tablets), 1 - 2 years - 0.0045 g (1 / 2 tablets), 2 - 4 years - 0.0675 g (3 / 4 pills) 4 - 7 years - 0,009 grams (1 tablet), 7-12-0.0135 g (1, 5 tablets), 12 - 15 years - 0,018 g (2 pills), over 15 0 027 g (3 tablets).

     The product is usually well tolerated by, but the possible pain, diarrhoeic phenomenon of pain in the heart; General weakness, cyanosis (nitrate). These phenomena are following the drug. Children should appoint a drug only with careful monitoring. For people with the enzyme deficiency in the blood glyukozo-6- fosfatdegidrogenazy may be severe vnutrisosudisty haemolysed with gemoglobinuriey (see Hinotsid). In severe cases, the picture reminds gemoglobinuriynuyu fever.

     In appointing primahina patients with symptoms of anemia and suspicion, the anomaly blood must be very cautious and regularly examine blood and urine; The first signs of change in colour of urine, a sharp reduction of the number or fair fight drug immediately repeal.

     The population of some parts of the Mediterranean, the Caucasus and Africa (particularly) are individuals with congenital deficiency glyukozo-6- fosfatdegidrogenazy, it is in these areas primaquine should be appointed with special care, not exceeding a daily dose of 0,015 grams per base (0, 027 g diphosphate) for adults; in the treatment requires careful monitoring of patients.

     It should not be taken simultaneously with primaquine Akri (primaquine delayed in the blood, and therefore increases its toxicity), and soon after Akrikhin (because of the slow allocation of Akrikhin organism), as well as with drugs, which can be activated and haemolytic oppress mieloidnye elements bone marrow (sulfanilamidy etc.).

     Primaquine contraindications people with acute infectious diseases (except malaria), in times of increasing rheumatism and other diseases that are characterized by a tendency to granulotsitopenii with diseases of blood and blood-forming organs, kidney disease, stenocardia. Do not apply primaquine with drugs, oppressive blood.

     Form release: pills (orange or light orange) for 0,003 and 0,009 city

     Storage: List B. Banks dark glasses.

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