PREDNIZOLON (Prednisolonum).

     Pregnadien-1, 4-triol-11b, 17a, 21-dion- 3, 20, or degidrogidrokortizon.

     Synonyms : Antisolon, Codelcortone, Cordex, Dacortin, Decortin H, Dehydrocortisol, Delta-Cortef, Deltacortril, Deltastab, Deltidrosol, Deltisilone, Hostacorlin H, Hydeltra, Hydrocortancyl, Mecortolon, Metacortalon, Metacortandrolon, Meticortelone, Nisolone, Paracortol, Precortalon, Prednelan, Prednisolone, Prenolone, Sterane, Sterolone, Ultracorten H et al.

     White or white with a yellowish sheen weak crystalline powder. Almost nerastvorim in water, soluble in alcohol.

     Prednisolone is degidrirovannym similar to hydrocortisone.

     The nature of the activity and close to prednizonu. Applied with rheumatoid arthritis, non-infectious polyarthritis, bronchial asthma, acute lymphatic leukaemia and mieloidnoy, infectious mononucleosis, neyrodermitah, eczema and other evidence to use glucocorticosteroids.

     There is evidence of the effectiveness of prednisolone with liver cirrhosis, chronic glomerulonephritis. Methods of prednisolone (and glucocorticosteroids) in infants.

     Assign prednisolone inwards in the form of tablets. Usually taken from (in severe cases) from 20-40 mg per day. In the future, to reduce the dose of 5 to 10 mg per day. These doses are supportive. Termination of treatment (as well as the application of other glucocorticoids) should gradually decreasing doses. And at the end of treatment should be a one-time 2 kortikotropin.

     Higher doses for adults inside : single 0,015 grams daily 0.1 g.

     Contraindications to the use of drugs such as prednisolone, as for other glucocorticosteroids.

     Product : pills containing 0,001 and 0,005 grams (1 and 5 mg) prednisolone.

     Storage : List B. In the dark spot.

     In an emergency requiring immediate increase corticosteroid in the blood (acute adrenal insufficiency, shock, asthmatic condition, asthma attacks, etc.) using soluble drug prednisolone injection-prednizolongemisuktsinat (see).

     For local applications with skin diseases nemikrobnoy etiology (eczema, itching, dermatitis, etc.) using 0.5% prednizolonovuyu ointment (Unguentum Prednisoloni 0.5%), which caused a thin layer of the skin 1 to 3 times a day.

     Product type : the aluminium tubes of 10 and 20 g.

     Storage : List B. In a cool place.

     Prednisolone is a member of the masi <<Dermozolon>> (see), and drug <<> (see Presotsil Hingamin).

     In Ophthalmic Practice (keratitis, konyunktivity, irity, blefarity etc.) using eye drops containing 0.3% solution hydrochloride-21 (dezoksi-N- metil-N'- piperazinil) - prednisolone. Assign 1 - 1 - 2 drops 3 times a day.

     Product : in 5 ml bottles.

     The drug is produced in Hungary.

     Possible side effects and contraindications to use eye drops with prednisolone, the same as in the application of eye drops with dexamethasone (see).

     In practice otorinolaringologicheskoy use ear drops containing 5 mg 0,025 21 g hydrochloride (dezoksi-N- metil-N'- piperazinil) prednisolone, 0.05 grams of ephedrine hydrochloride and 0,025 grams of local anaesthetics lidocaine.

     Assign 4 - 5 drops of 3 to 4 times a day in ears or nose with a half pneumonia and eczema external audible passage allergic diseases ear cavity, with vazomotornyh and allergic rhinitis, etc.

     The so-called <<Aurobin>> (Aurobin) issued (in Hungary) ointment containing 20 grams (one tube) 0.04 g kaproata prednisolone, 0.4 g anaesthetics lidocaine and auxiliary substances.

     When applied itch back passage, eczema and dermatitis perineum, gemorroidalnyh knots, cracks in the rear walkway.

     Apply a thin layer to the affected lots 2 to 4 times a day. With deep gemorroidalnyh knots ointment impose in a small number of rectum 2 to 4 times a day.

     It applied ointment to viral infection, in the first trimester of pregnancy.

     When fungal defeat must simultaneously appoint antifungal.

     Product type : the aluminium tubes of 20 g.

     Storage : Keep in a cool place.

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