PREDION FOR INJECTION (Predionum pro injectionibus). 5-? Pregnan- ol-21- - Dione-3, 20 2l- monosuktsinata sodium salt.

     Synonyms: Viadril, Hydroxydioni Natrii succinas, Hydroxydione Sodium succinate, Pregnocin-natrium, Presuren, Viadril.

     White or white with a yellowish tinge porous mass or powder. Soluble in water. Solutions are alkaline reaction (p 8 H, 5-9, 5).

     On chemical structure similar to predion steroidnym hormones, but no hormonal properties, and has widespread and drug action.

     Apply for intravenous induction, the base, as well as for self mononarkoza. By induction predionovomu anaesthesia resort where combination barbiturates. Application prediona base for anaesthesia (in conjunction with air, nitrogen oxide, ftorotanom) can reduce the number of core funds for anaesthesia necessary for anesthesia. The preparation of the muscles potentsiruet judgement that allows them to reduce the dose.

     Prediona narcotic effect after a single intravenous usually (30 -40) min.

     Solutions prediona injection prepare just before use. As a solvent used 5% glucose solution, isotonic sodium chloride solution 0.25% solution Novocaine or sterile water for injection.

     Apply predion in solutions of different concentrations (from 0.5% to 5%), more frequently used 2 - 5 5% solution.

     Initial dose to anaesthesia induction of 10 - 12 mg / kg and for the base and self-anaesthesia 15 - 20 mg / kg. The total dose varies depending on the type of anaesthesia, and the weight of the patient from 0.5 to 3, 5 grams or more if necessary. Enter solution in a large-calibre veins (usually second) through needle with a large clearance. The speed of 1 g within 3 to 5 minutes. Enter product vein in the lower limbs and small vein is not recommended because of this irritation more frequently vascular wall. The introduction of the drug under the skin is not allowed.

     Effects prediona is usually through 3-5 minutes. after the introduction. Drip a 0.5-1% solution is superficial anaesthesia in 15 - 20 minutes. Continuation of the drip can be sustained superficial anaesthesia.

     Predion well relaxing musculature not have a significant impact on respiration and the cardiovascular system. In connection with malovyrazhennym impact on carbohydrate exchanges can be used in sugar diabetes.

     The main complication is the use prediona irritation vnutreney wall veins, accompanied by pain on the vessel during the course of the drug; Further possible sealing veins and flebita. To prevent this complication in the application prediona recommended as a solvent solutions use glucose, sodium chloride and Novocaine; In addition, prior to the introduction prediona should introduce veins 0,25 - 0,5% solution of Novocaine, but after the introduction prediona (not removing the needles from a vein) "wash" veins of the solvents (10 to 20 mL).

     If you have more in a solution prediona should massage the forearm and give limbs emotive situation.

     Stays are contraindications to the use prediona.

     Now is not widely applied in the clinic.

     Form release: in sealed vials or ampoule with a capacity of 20 ml with 0.5 g of the drug.

     Storage: List B. In sheltered from the world scene. 3 also issued a foreign drug <> (G Viadril <Viadril G>) containing viadril (predion) with the addition glikokola. The product has a lower than normal viadril, irritant effects on the vascular wall.

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