PRAZOZIN (Prazosinum). 1-(4-Amino-6, 7-dimetoksi-2- hinazolil) -4 - (2-furoil) - piperazine hydrochloride.

     Synonyms : Adverzuten, Deprazolin, Minipress, Pratsiol, Adversuten, Decliten, Deprazolin, Duramipress, Eurex, Furazosin-hydrochloride, Hypovase, Minipress, Orbisan, Patsolin, Peripress, Pratsiol, Prazac, Prazopress, Prazosin, Sinetens; Vasoflex and others.

     The white crystalline powder with a white or yellow color kremovatym, very little soluble in water.

     Prazozin is a-adrenoblokiruyuschim anti-hypertensive drug, used in hypertension and congestive heart failure.

     Prazozina feature is its selective effect on vascular postsinapticheskie a 1-adrenoretseptory that distinguishes it from a normal-adrenoblokatorov such as fentolamin, and the other blocking a time, a 1 and a 2-adrenoretseptory blood vessels. Consequently prazozin blocks sosudosuzhivayuschee a mediator (noradrenalina) without effect on other types of activity.

     Characteristic of action prazozina is mainly peripheral vazodilatatsiya. He has a arterio- and venorasshiryayuschee action (with some impact on volumes, ie venous, vascular), decreases in connection with the venous flow of blood to the heart and facilitates the work of the heart due to the reduction of peripheral resistance, ie reducing crime and postnagruzku to attack. Reducing minute of it is preparation.

     Unlike a conventional-adrenoblokatorov prazozin tachycardia usually is.

     In mechanism sosudorasshiryayuschego effect prazozina played a direct spasmolytic effects associated with its inhibiting effect on fosfodiesterazu (see Theophylline).

     According to reports, prazozin beneficial impact on serum lipids. The drug also reduces aggregation erythrocytes.

     Prazozin applied to various forms of hypertension. Prazozina growing anti-hypertensive effect in combination with tiazidnymi diuretikami, b-adrenoblokatorami antigipertenzivnymi and other drugs. Due to the lower load on the heart is also used to treat congestive heart failure.

     Prazozin eliminates vazospasticheskie reaction coronary arteries. The drug often active in the poor antigipertenzivnyh other drugs, including calcium antagonists ions.

     Is prazozin inside regardless of meal times. Beginning with a small dose - 0.5-1 mg to be taken at night, after which the patient must stay in bed for 6 to 8 h. This is the opportunity of development "phenomenon first dose of" postural hypotension until unconscious state (collapse). Especially expressed this reaction in the face of previous admission diuretikov.

     Later appointed prazozin to 1 mg 3 or 4 times a day. Gradually increase the dose, making anti-hypertensive effect. The effect usually comes in a few days, but persistent lowering blood pressure can develop through 4 - 8 weeks. Supporting dose prepared individually and can range from 3 to 20 mg per day, more often, it is 6 to 15 mg per day. The daily dose is divided by the 3 - 4 reception, setting optimal treatment. Some patients from the two active drug use. In monotherapies prazozinom should take into account the possibility of an early (3 - 5-day) or later (a few months) tolerance (adjusting) to the drug. This requires an increase in daily dose of 1 mg prazozina or more an additional destination diuretikov.

     With low or slow-developing anti-hypertensive effect prazozin combine with diuretikami, b-adrenoblokatorami, klofelinom antigipertenzivnymi or other means. In this case, dose prazozina reduced to 1 to 2 mg three times a day while adding products, which are in treatment, and then gradually increase again, selecting appropriate treatment regime.

     In congestive heart failure prazozin designate dose of 3 to 20 mg per day for 3 to 4 admission, observing normal for this product precautions (first dose should not exceed 0.5 mg; After receiving the patient must also be in a lying position). Dose increase gradually.

     As a adrenoblokator - prazozin can also be applied to violations of peripheral blood circulation.

     An important feature prazozina discovered recently, is effective in the conservative treatment of patients with adenoma prostate gland in the early stages. The operation was based on the fact that the violation of urination in patients with adenoma prostate gland is highly correlated with increased anxiety-adrenoreceptor a reason bladder, and a blockade-adrenoreceptor bladder neck, the back of the urethra and prostate gland momentum improves urination.

     When prostate gland adenoma prazozin designate the interior of a meal. The first dose equal to 0.5 mg, taken at night. Next appoint 1 mg, 2 times a day for a week. Then increase the dose of 4 mg / day (1 mg four times a day). If expressed anti-hypertensive reaction daily intake should be reduced to 2 mg. Module 8 weeks of treatment, if necessary, can be extended. Upon termination of treatment patients can be applied : supporting dose of 2 mg / day (1 mg 2 times a day).

     In applying prazozina than the "phenomenon of the first dose, the following possible side effects : dizziness, headache, insomnia, weakness, fatigue, nausea, diarrhea, constipation, dry mouth. Usually these events are themselves.

     Despite the vote, a adrenoblokiruyuschee-effects, in some cases, possibly increasing heart. Please note that the drug's holinoliticheskoy moderate activity.

     There are indications that anti-hypertensive effect prazozina increased in intensity and duration to age, and therefore for middle-aged and elderly should carefully select doses.

     The drug is contraindicated in pregnancy. Do not appoint him children under the age of 12 years. Patients with kidney failure drug appointed in small doses with caution.

     Product : pills for 0,001 and 0,005 grams (1 and 5 mg) with risk, in a package of 50 or 100 pieces.

     Storage : List B. In the dark spot.

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