PRAZIKVANTEL (Praziquantel). 2 - (Tsiklogeksilkarbonil) -1, 2, 3, 6, 7, 11b- hexahydro-4 H pirazino [2, 1-a] - izohinolin-4- it.

     Synonyms: Biltride, Cesol, Cestox, Cistricid, Droncit, Pyquiton.

     Patriotic called Azinoks "(A zinox).

     The white crystalline powder, bitter taste.

     It is highly effective for the treatment and shistosomatozov trematodozov.

     Quickly absorbed in the employment inside. Peak concentrations in the blood plasma through a 1 - 2 hours Fast product and return up to 80% of kidney metabolites during four days, with 90% of output in the first 24 hours

     In the mechanism of action prazikvantelya important to increase his influence permeability of cell membranes parasites for calcium ions. The product is reduced musculature parasites, rolling in spastic paralysis.

     Assign praziquantel interference in 1 - 2 days. Is usually a day to 25 mg / kg 3 times 30 or 40 mg / kg 2 times.

     The product provides high thermal effect (up to 100%) and generally well tolerated by. In some cases, there are nausea, headache, pain in epigastralnoy area. These phenomena are usually after receiving the drug.

     Compared with praziquantel hloksilom more efficient and better postponed.

     Form release: pills.

  3. ANTIMONIL- SODIUM TARTRAT (Stibii et Natrii tartras).

     Synonyms: Vinnosurmyannonatrievaya salt Sodium vinnosurmyanokisly, Natrium tartaricostibium, Sodium Antimony tartrate, Stibii et Natrii tartras, Stibnal, Stibyal, Ta rtarus Stibiatus natronatus.

     The white crystalline powder. Soluble in water.

     Used to treat shistosomatozov. Because of the complexity of and adverse events is not widely used.

     Enter intravenously in a 1% solution of isotonic sodium chloride solution with the addition of 5% glucose. A solution must be svezheprigotovlennym, sterilizovannym in autoclave or a water bath. Enter slowly (no more than 2 ml / min). Treatment hold only in a hospital.

     Proposed various schemes. 1. The product is entering a daily basis, only 20 injections. Single dose (she also daily) 1 0-1 2 mg / kg. The total dose of treatment should not exceed 1 / 3 g drug (130 mL 1% solution). To avoid side effects dose after 10 - 11 injection slightly lower, with a 15-second injection once more. For example, a patient weighing 60 kg enter first 5 ml of 1% solution of the 2 nd and 11 rd injection-to 7 ml of the same solution, with the 12 th and 15 th injection of 5 ml, and the 16 th and 20 th inektsiyu-to 7 ml (total 130 ml). 2. Intensive Course: treatment in 1 - 2 days. Making 3 injections a day at intervals of 3 hours. An adult dose of 0,06 - 0,12 (6-12 ml of 1% solution).

     There are other schemes treatment.

     Note that the application offers different drug side effects: nausea, vomiting, headache, arthralgia, skin rashes, increased body temperature, etc. In order to reduce the side effects appoint protivogistaminnye drugs unitiol. If necessary, further introduction of a drug stop.

     In place of intravenous can develop phlebitis; Hit solution under the skin and cause severe pain of making tissue swelling.

     Contraindications: organic heart disease, kidney disease and liver (non-worm), pregnancy, depletion, advanced age, menstruating.

     Form release: powder.

     Storage: List B.

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