PRAVASTATIN (Pravastatin).

     Geksagidro-? ,? 6-trioksi-2- metil-8- (z-methyl Okseo butoksi) -1 - naftalingeptanoevoy acid sodium salt.

     Synonym : Lipostat, Lipostat.

     White or colourless crystalline powder. Well soluble in water, not in isopropanol, almost nerastvorim in acetone, chloroform and acetonitrile.

     On chemical structure and the mechanism of close to lovastatinu and other statins. In the body of a whole molecule (unlike lovastatina).

     In the digestive tract is not fully absorbed (up to 54% of dose), C max is 1-1,5 h, T? about 77 h; biotransformation exposed in the liver, allocated mainly to the faeces.

     Assign with Moyle type II without IBS, atherosclerosis, IBS (including myocardial infarction) and family NCEP.

     According to published data overseas, in patients with IBS and NCEP long (up to 3 years) application pravastatina along with a pronounced effect gipoholesterinemicheskim said reducing progression of coronary atherosclerosis and the risk of complications (lower total and cardiovascular mortality ", the frequency of heart attacks). The drug has proved effective and the primary prevention of coronary heart disease, in patients with NCEP expressed, but no sign of cardiovascular disease occurred reliable overall decline "and" coronary mortality, as well as the frequency of non-fatal heart attacks.

     Assign inside of 0,01-0,04 g (10-40 mg) a day (at night). With at least four weeks to correct dose.

     Possible side effects : increased pancreatitis, myo, arthralgia, disruption of the liver, acute renal failure in the face rabdomioliza, reduced libido, the progression of cataracts, allergic reactions, etc.

     Pravastatin is not suitable for liver diseases, pregnancy and breastfeeding.

     Makrolidnye antibiotics, nicotinic acid and other gipoholesterinemicheskie drugs increase the risk of developing rabdomioliza with acute renal failure. Reinforces anti proximity effect.

     Product : pills to 0.01 g and 0.02 g (N. 10, 20).

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