POLIMIKSINA M SULFAT (Polymyxini sulfas M).

     Polimiksinami group called Allied antibiotics produced spore soil bacteria Bacillus polymyxa or other relevant microorganisms. On chemical structure polimiksiny are complex compounds comprising residues polipeptidov. Different polimiksiny have an additional letter. Polimiksin M is one of polimiksina.

     Polimiksin M sulfate-white or white with kremovatym nuance bulk powder or porous mass sladkovato- bitter to the taste. The easily soluble in water.

     The drug activity is defined by biological and expressed in action (ED); 1 mg contains 8000 ED.

     Polimiksin M operates mainly in gram-negative microorganisms : delayed growth and intestinal dysenteric sticks, sticks typhoid and paratyphoid; Effective on Bluepus wand. It operates at proteus, Gioacchino gram, micobacterium, mushrooms.

     Polimiksin M malotoksichen with local application. When ingestion poorly absorbed from the gastrointestinal tract and is not toxic to the body. In a parenteral drug toxic : Provides nefro- and neurotoxic effects.

     Assign polimiksina M sulfate and External interference; A man is not allowed.

     Locally applied polimiksin M in various low current processes : low healing wounds, infected burns, necrotic ulcers, bedsores, introducing otites, inflammatory diseases of the eye and ear, abscesses and other investments diseases caused by Escherichia Coli and micro gram. The preparation is used as linimenta or solution being prepared immediately before use at the rate of 10000-20000 ED 1 ml isotonic sodium chloride solution, or 0.5-1% solution of novocaine.

     Solutions used to soak tampons, casts, and for irrigation in the form of drops.

     Liniment cause thin layer of skin surface (after removal of cancer and necrotic masses) 1 to 2 times a day, with burns 2 to 3 times a week. Daily intake of a local application of no more than 20,000 ED (2 mg) for 1 kg of body weight. Duration of treatment 7 to 10 days.

     Inside designate polimiksin M kishechnih with gastrointestinal illness (colitis, enterocolitis, gastroenterokolity) caused by gram bacteria and Escherichia Coli. Recommended drugs in acute and chronic dysentery in cases where other antibiotics ineffective. Ïðåïàðàò ìîæåò ïðèìåíÿòüñÿ äëÿ ïîäãîòîâêè áîëüíûõ ê îïåðàöèÿì íà æåëóäî÷íî-êèøå÷íîì òðàêòå.

     Polimiksin M may be nominated in combination with other antibiotics, acting on micro gram.

     Inside designate polimiksina M sulfate tablets. Dose adult ED 500000 4-6 times a day; Daily intake 2000000 3000000 - ED. Daily intake for children aged 3 to 4 years - 100000 ED 1 kg of body weight; Allow 3 to 4 admission; At the age of 5 to 7 years; Single dose 350000 ED, ED 1.4 million daily; 8-10 years : single 400000 ED, ED daily 1.6 million, 11-14 years : single 500000 ED, ED 2 million daily. The length of treatment depends on the nature and severity of the disease (average 5 - 10 days). When relapse after a (3 to 4 days) can be assigned to the second course of treatment.

     In oral and local application polimiksina M sulfate side effects are usually not indicated. In some cases, especially with long-term care high doses, possible changes in the kidneys. The treatment must be carried out continuously monitored for kidney function; Urine tests must be conducted at least once in two days. Possible allergic reactions. Liniment can provide local irritant effect (Blush skin rashes).

     The drug is contraindicated in violation of the liver and kidneys, with individual intolerances.

     Method of issuance : in vials of 500000 and 1000000 ED drug; 500,000 tablets of ED; Liniment, contains 10,000 ED polimiksina M sulfate in 1 g (with the addition anestezina and nipagina). Liniment white or white with a yellowish sheen color issued to 30 g tubes and glass banks.

     Storage : List B. In dry, the dark spot.

Materials allowed to copy only with the active hyperlink to the handbook of medicines