POLIMIKSINA M SULFAT (Polymyxini sulfas M).

     Polimiksinami group called Allied antibiotics produced sporoobrazuyuschimi soil bacterium Bacillus polymyxa or other related pathogens. On chemical structure polimiksiny are complex compounds comprising residues polipeptidov. Different polimiksiny have additional letter. Polymyxin M is one of polimiksina.

     M sulfate-polymyxin white or white with a touch kremovatym bulk powder or porous mass bitter sweet taste. Easy soluble in water.

     The drug activity is defined by biological and expressed in units of (ED); 1 mg contained in the 8000 ED.

     Polymyxin M operates primarily on micro gram: delayed growth and intestinal dysenteric fingers, fingers typhoid and paratyphoid; Effective in Pseudomonas sticks. It operates on Proteus, gram Cocchi, Mycobacterium, mushrooms.

     Polymyxin M malotoksichen with local application. When you receive inside poorly absorbed from the gastrointestinal tract and is not toxic to the body on. When parenteral a toxic product: providing nefro- and neurotoxic effects.

     Assign polimiksina M sulfate inside and externally; Parenteral introduction is not allowed.

     Local use polymyxin M in various low current processes: weak healing wounds, infected burns, necrotic ulcers, bedsores, treat otitis, inflammatory eye and ear diseases, abscesses and treat diseases caused by Escherichia sticks and micro gram. The product is used as linimenta or solution, prepared just before use for 10000-20000 ED 1 ml isotonic sodium chloride solution, or 0.5-1% solution of Novocaine.

     Solutions used to soak minutes, dressing, and for irrigation in the form droplets.

     Liniment cause a thin layer of skin surface (after removing come and necrotic masses) 1 to 2 times a day, with burns 2 to 3 times a week. Daily dose to the local application of no more than 20,000 ED (2 mg) for 1 kg of body mass. Duration of treatment for 7 to 10 days.

     Inside appoint polymyxin M kishechnih with gastrointestinal illness (colitis, ac, gastroenterokolity) caused by gram bacteria Pseudomonas and sticks. Recommended drugs in acute and chronic dysentery in cases where other antibiotics ineffective. The product can be used to prepare patients for operations in the gastrointestinal tract.

     Polymyxin M can appoint, in combination with other antibiotics, operating at the micro gram.

     Inside appoint polimiksina M sulfate tablets. The dose for adults 500000 ED 4 to 6 times a day; Daily intake 2000000 3000000 - ED. Daily dose for children aged 3 to 4 years - 100000 ED 1 kg body weight; Allow 3 to 4 admission; At the age of 5 to 7 years; Single dose 350000 ED, ED 1.4 million daily; 8-10 years: single 400000 ED, ED daily 1.6 million, 11-14 years: single 500000 ED, ED 2 million daily. The length of treatment depends on the nature and severity of the disease (average 5 - 10 days). In return, after the break (3 - 4 days), you can assign a second treatment.

     In oral and local application polimiksina M sulfate side effects are usually not mentioned. In some cases, especially with long-term high-dose treatment, there may be changes in the kidneys. Therefore, treatment should be continuously monitored for kidney function; Urine tests to be made at least once every two days. Possible allergic reactions. Liniment can provide local irritant effects (skin redness, rash).

     The product contraindications for violations of the liver and kidneys, with individual intolerance.

     Method of issuance: in vials of 500000 and 1000000 ED drugs; 500,000 tablets of ED; Liniment, contains 10,000 ED polimiksina M sulfate in 1 g (with the addition anestezina and nipagina). Liniment white or white with a yellowish tinge color ink issued to 30 grams and glass banks.

     Storage: List B. In a dry, sheltered from the world scene.

Materials allowed to copy only with the active hyperlink to the handbook of medicines