PODOFILLIN (Podophyllinum).

     Synonym : Neorondeks, Neorondexum

     A mixture of natural compounds obtained from the rhizomes with roots podofilla thyroid gland (Podophyllum peltatum L.), herewith. barbarisovyh (Berberidaceae).

     Contains podofillotoksin (at least 40%), a-and b-peltatiny.

     Amorphous powder or mass of yellow-brown to yellow-green to a specific smell.

     Extracts from the root podofilla long been used in folk medicine as softeners, and keep protivoglistnyh drugs. Later, it was found that they had a cytostatic activity and block mitozy under metafazy said that the actions kolhitsin.

     As an antitumor means podophyllum found use in the treatment of papillomas - papillomatoza larynx and bladder papillomas.

     There are also data on the treatment podofillina limfangiom.

     In papillomatoze larynx children, first papillomas removed surgically, and then one every two days cuticles of mucous membranes at the disposal of 15% alcohol solution podofillina. The course of treatment 14 16 lubricating. Children under 1 year should be used with caution preparation. Adult cuticles larynx 30% alcohol solution podofillina 10 times, then remove adolescents and again cuticles 20 times. In the absence of inflammatory responses, cuticles daily, with the inflammatory response-1 every 2 or 3 days.

     Suspension podofillina give the bladder with few typical and atypical fibroepiteliomah fingerprint. Combined with elektrokoagulyatsiey podophyllum apply for relapse prevention. In entering the bladder through the catheter 1%, 4%, 8% or 12% suspensions podofillina in vaseline oil in the amount of 100 ml at 30-40 min or 1 - 2 hour, one week. After infusion of the patient must be for some time based on one, then the other side.

     In applying podofillina is burning in the urinary bladder, which was once the drug.

     When lubricating larynx appear nausea, vomiting, gastrointestinal disorders, drug cease further use.

     Product : powder on 100 or 200 grams in banks orange glass.

     Storage : List A. dry, the dark place at room temperature.

     Note.

     With preparation (cooking solutions, mist, etc.) to avoid diversion of conjunctival should work points.

     Abroad, on the basis of substance podofillina - podofillotoksina received semi-glycosides etopozi d (Etoposide) and Teniposide (Teniposide), effective for certain types of tumors. Etoposide has practical applications as anticancer funds. Teniposide is under further investigation.

Materials allowed to copy only with the active hyperlink to the handbook of medicines