PIRILEN (Pirilenum). 1, 2, 2, 6, 6-Pentametil- PIPERIDINE paratoluolsulfonat.

     Synonyms: Pempidine tosylate, Pempidini tosylas. Similar tartrate produced abroad under the title: Re mpidinum, Re rolysen, Synapleg, Te normal etc.

     White or white with kremovatym white crystalline powder. Easy soluble in water and alcohol.

     Pirilen a tertiary amine. Relatively with Quaternary ammonium compounds pirilen better absorbed in the employment inside and provided with a means of rapid ganglioblokiruyuschy and hypotensive effect. Pirilen permeates through cross the blood-brain barrier and has an impact on the central locking n-holinoretseptory.

     Apply pirilen with peripheral vascular cramps, stomach ulcer disease and stomach cancer, toxaemia pregnant. In hypertensive disease pirilen can be used in combination with other means gipotenzivnymi (Reserpine, dihlotiazid etc.).

     Assign: inwards in the form of tablets, from 0.0025 g dose (2, 5 mg = 1 / 2 tablets); Portability with a good dose of an increase to 0,005 g 2 - 3 - 5 times per day.

     Treatment pirilenom conduct courses for 2 - 4-6 weeks with breaks between courses 2 - 3 weeks. When the blood pressure drug may gradually rise again.

     When hypertension associated with the late toxaemia pregnant, single dose is usually 0.01 g (2 pills).

     There is evidence of the successful application for pre pirilena training in patients with pulmonary hypertension and chronic pulmonary heart.

     Higher doses for adults inside: off 0.01 g, 0.03 g daily:

     Possible side effects such as the application of other ganglioblokatorov.

     In applying for pirilena often Constipation, abdominal distension, and the simultaneous admission to stimulants (Phenolphthalein, magnesium sulfate or other) and the appropriate diet.

     Pirilen contraindications to sharply pronounced atherosclerosis, organic defeat Chavez, zakrytougolnoy glaucoma, as a violation of the liver and kidney, stomach and bowel atony.

     Form release: pills to 0,005 grams (5 mg).

     Storage: List B. The well ukuporennoy packaging.

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