PIRENTSEPIN (Pirenzepine). 5, 11 Digidro-11--[4-methyl piperazinil) acetyl] -6 H pirido [2 3-b] [1, 4] benzodiazepin-7- he digidrohlorid.

     Issued in the form dihydrochloride.

     Synonyms: Gastrozepin, Gastrotsepin, Pirenzepin, Abrinac, Bisvanil, Duogestral, Gasteril, Gastrol, Gastropin, Gastropiren, Gastrozepin, Leblon, Pirezam, Pirigast, Ulcepin, Ulcin, Ulcopir, Ulcosan, Ulcozepin and others.

     Pirentsepin is a new sub antiholinergicheskih substances-specific blockers M1- holinoretseptorov. In contrast to the "typical" M-blockers holinoretseptorov (atropine, etc.) pirentsepin selectively oppresses gland secretion of stomach acid and hydrochloric pepsinogena not have significant impact on M-blocking holinoretseptory salivary glands, heart, smooth muscle eyes and other organs.

     Effects pirentsepina secretion of digestive blockage due M1- holinoretseptorov at intramuralnyh gangliev off and thus incentive effects on the digestive nerve selective secretion.

     The product suppresses basement and stimulated secretion of hydrochloric acid and pepsinogena and quickly reduces the overall activity of digestive juice.

     Apply for the treatment of acute and chronic stomach and duodenal ulcers, high acidity gastritov digestive juice, genital lesions gastrointestinal tract associated with the use of non-steroid anti-funds (see), etc.

     Assign inside and parenteral transmission: the interior of 0.05 g (50 mg) morning and evening for 30 minutes before meals; ?high small amount of water. The course of treatment for at least 4 weeks (4 to 8 weeks) without interruption. With rapid subjective improvement should not continue receiving the drug because of the possibility of degradation.

     Early treatment combination oral and parenteral introduction: one dose intramuscularly enter, take one inside.

     Intramuscularly or intravenous drug use mainly in the form of heavy stomach and duodenal ulcer disease diagnosis, treatment and prevention of bleeding, erozy and pitting. Enter intramuscularly and intravenously (slow) to 10 mg (1 vials) every 8-12 h. When the disease Zollinger-Ellison double dose increase.

     After improvement (in 2 to 3 days) move on to receive the drug inside.

     Pirentsepin dissolve immediately before use. Complete solutions should be used for no more than 12 hours

     To make Infusion solution pirentsepina razvodyat in isotonic sodium chloride solution, or 5% glucose solution.

     If necessary, you can combine the application gastrotsepina and antiulcer drugs (antisekretornyh), in particular gistaminovyh N2- receptor blockers (see Tsimetidin). At ability ingibirovat secretion of hydrochloric acid, 50 mg pirentsepina equivalent to 200 mg tsimetidina.

     Pirentsepin certainly effective as antiholinergicheskoe protivoyazvennoe funds, but the issue of its advantages over conventional holinolitikami (atropine, metatsin, hlorozil) with intensive kislotoobrazovanii insufficiently studied.

     Moved pirentsepin generally good. Sometimes there is drought in the mouth, slightly short of a violation. Through product not cross the blood-brain barrier penetrating, and the central holinoliticheskogo action is not

     With intravenous introduction should be monitored cardiovascular system.

     The product should not be used in the first three months of pregnancy.

     Caution should be observed in the appointment pirentsepina patients with glaucoma with thyroid prostate gland.

     Method of production: tablets of 25 mg and 50 in a package of 50 and 100 pieces; Capacity 2 ml ampoule containing 10 mg dry drug application with solvent, in a package of five vials.

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