PIRAZINAMID (Pirazinamidum).

     Amid pirazinkarbonovoy acid.

     Synonyms: Tizamid, Aldinamid, Cavizide, Eprazin, Farmizina, Isopyrasin, Novamid, Piraldina, Pyracinamide, Pyrazinamide, Tebrazid, Tisamid, Zinamide.

     The white crystalline powder. Soluble in water when heated.

     More active on tuberkulostaticheskoy activity than PASK, although less isoniazid, streptomycin, rifampicin, tsikloserinu, etionamidu, kanamycin, florimitsinu. Force Mycobacterium resistant to other drugs protivituberkuleznym I and II series. The product is well into the pockets of TB lesions. His activism has not decreased in the acid environment kazeoznyh masses, therefore, it is often appointed to kazeoznyh lymphadenitis, and tuberkulomah kazeozno- pnevmonicheskih processes.

     When treating a pyrazinamide possible to the rapid development of resistance testing tuberculosis, so it is usually combine with other anti-tuberculosis drugs (isoniazid, streptomycin etc.).

     The product is particularly effective in patients with first identified destructive tuberculosis.

     Daily dose of pyrazinamide for adults, 1 5-2, 0 g, with good portability to 2, 5 g per day. Accepted inside after eating at 1 g 2 times (less than 0.5 grams of 3 - 4 times) a day. Daily dose for patients over 60 years of age and weighing up to 50 kg-1, 5 Children was nominated for 0,02 - 0,03 g (20 - 30 mg) for 1 kg of body weight per day (daily intake of not more than 1, 5 g).

     When treating pyrazinamide may be allergic reactions: dermatitis, eosinophilia, feverish reaction, etc. There are also diarrhoeic phenomenon, the deterioration of appetite, headache, occasionally, increased anxiety, concern. In a lengthy application can have toxic effects on the liver.

     In the treatment pyrazinamide to monitor liver function through biochemical samples (timolovaya samples, the identification of bilirubin, a study glutaminoschavelevokisloy aminoferazy blood serum, etc.). When there are changes in liver function ceased to receive the drug. To reduce the toxic action pyrazinamide recommended the appointment of methionine, lipokaina, glucose, vitamin B.

     There is evidence of the delay in the body under the influence of pyrazinamide uric acid and improvements in the joints of arthritic pain, it is therefore the content of uric acid in the blood.

     Contraindications: violation of liver function and gout.

     Form release: pills for 0.5 and 0.75 g.

     Storage: List B.

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