FITOMENADION (Phytomenadionum).

     Fitomenadion is vitamin K 1.

     Synonyms: Eleven K, Fimedion, Fitonadion, Konakion, Konavit, Mephyton, Monodion, L-Phyllochinon, Phytonadione and others.

     For medical applications received by synthetic means.

     Yellow or orange-yellow transparent viscous liquid with low odor. Almost nerastvorim in water, soluble in alcohol little, easily soluble in vegetable oils. Situated at the light.

     Unlike natural vitamin K 1 (cross-connect) is a synthetic drug ratsemicheskoy form (a mixture of cis-and trans-isomers), but the biological activity of synthetic drugs remains properties of natural vitamin C.

     Apply fitomenadion with curative and preventive effect.

     When you receive a product inside quickly absorbed. It usually occurs in the blood half an hour later after admission. Peak concentrations in the blood plasma by a 2 to 8 h. Pridukty metabolism made with urine and bile.

     If any secretion and, in intestinal epithelial stripping slowing.

     Fitomenadion appointed with haemorrhagic syndrome with gipoprotrombinemiey caused by violation of the functions of the liver (hepatitis, liver cirrhosis) and some diseases gastrointestinal tract (stomach ulcer disease, colitis, etc.). In addition, the drug used to haemorrhage, related to the application (overdoses, individual high sensitivity) antikoagulyantov indirect action (kumarinovogo and indandionovogo number) and some other drugs (antibiotics, salitsilatov, sulfanilamidov, tranquilizers). Also appointed to the heavy operations to reduce bleeding.

     Fitomenadion take inside 30 minutes after eating.

     A drug treatment to appoint 0,01 - 0,02 g 3 -4 times a day, sometimes up to six times a day. Dose and duration of treatment, depending on individual performance gemokoagulyatsii (protrombinovy index tromboelastogramma, koagulogramma, tolerance to blood geparinu etc.).

     When overdose antikoagulyantov enough treatment from 2 to 5 days to less than 10 days, with liver disease and gastrointestinal tract, from 7 to 25 days.

     On the preventive end fitomenadion appoint 0.03 grams a day during the 3 - 4 days before the operation.

     Contraindications Elevated blood and pulmonary youngest.

     Form release: 10% solution in the oil capsules of the drug 0.01 g (0.1 ml of solution).

     Storage: a dry, sheltered from the world scene at room temperature.

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