Ftivazid (phthivazidum)


FTIVAZID (Phthivazidum). 3-methyl oksibenzilidengidrazid izonikotinovoy acid, or izonikotinoil- (3-methyl oksibenzal) - gidrazon.
     Synonyms: Ftivazidum, Vanicide, Vanillaberon, Vanizide.
     Light yellow or yellow powder melkokristallichesky with sla6 th smell vanillin, without taste. Very little soluble in water, in little-alcohol, easy-to inorganic acids, alkali.
     For chemotherapy properties and testimony to the use of close to isoniazid.
     Compared with isoniazid slowly absorbed from zheludochnokishechnogo tract; If its application is somewhat lower concentration gidrazida izonikotinovoy acid in the blood.
     Accepted ftivazid inside. Relatively with isoniazid, it will be postponed and may be appointed in bad portability isoniazid.
     Average daily intake for adults, 1 0-1, 5 g (0.5 g for 2 to 3 times a day); For children at the rate of 0.02 - 0.03 - 0.04 g / kg (20 - 30 - 40 mg / kg) is not more than 1, 5 grams a day three times a day.
     In ordinary (TB) Lupus appoint 0.25 - 0.3 g 3 - 4 times a day at the rate of 40 in 1960 to achieve clinical cure such courses repeat 2 - 3 times per month break.
     Higher doses for adults inside: single 1 g daily 2 grams.
     Possible side effects are similar to those observed in the application of isoniazid. They recommended the use of pyridoxine (see Izoniazid).
     Contraindications: stenocardia and heart defects with decompensation, organic TSNS disease, kidney disease netuberkuleznogo nature, coupled violation vydelitelnoy functions.
     Method of issuance: powder, pill for 0.1, 0.3 and 0.5 g in the package of 100 pieces.
     Storage: List B. The well ukuporennoy packaging.

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