FOTRIN (Photrinum). 2, 2, 4, 4, 6-Pentaetilenimino-6- morfolinotsiklotrifosfazatrien.

     Synonym: Fotretamine.

     The white crystalline powder. Easy soluble in water and alcohol.

     It has antitumor activity (protivoleykoznoy). Granulotsitopoez oppresses and to a lesser extent eritro- and trombotsitopoez.

     Apply in chronic leukemia (at the level of cells above 100 ? 10 9 / L), with eritremii, and mushroom Mycobacterium, the primary retikuleze skin retikulosarkomatoze, angioretikuleze Kaposi with ovarian cancer.

     Enter fotrin intravenously, intramuscularly or in cavities (vnutribryushinno).

     Before the introduction of the contents of ampoule (10 or 20 mg dry) dissolve in isotonic sodium chloride solution (in five or 10 ml).

     In chronic leukemia fotrin enter through the day, starting with the occasional dose of 5 mg. In the future, good portability single dose increase to 10 to 15 mg. The total dose varies widely depending on the severity of the disease and the effectiveness of therapy.

     In eritremii imposed on 40 mg a day. In the course of 280-360 mg. In the case of repeated relapse treatment.

     In gemodermiyah impose 2 - 3 times a week for 10 to 15 mg per day. With a good dose of portability increase to 20 to 25 mg. At treated 150-250 mg.

     When ovarian cancer impose fotrin intravenously or intramuscularly (10 of 15 mg a day) or intravenously (intramuscularly), while the introduction of abdomen dose of 20 to 40 mg once. Exchange dose to 300 mg.

     In applying fotrina requires regular monitoring of blood picture in the treatment process, and during the two weeks after. Possible common side effects and contraindications such as the application of other products in this group.

     Form release: in dried form ampoule of 10 or 20 mg (R hotrinum et 0,01 0,02 pro injectionibus) - white or white with a slightly yellowish tinge porous mass or powder in a package of 10 vials.

     Storage: List B. When temperature is not above + 10 C.

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