FOSFESTROL (Phosphoestrolum).

     Sodium salt difosfornogo ether trans-3, 4-di - para-oksifenilgeksena-3.

     Synonyms: Honvan, Cytonal, Difostilben, Fosfestrol, Fosfostiben, Honvan, Honvol, Stibostatin, Stilphostrol and others.

     White or white with a touch kremovatym melkokristallichesky powder. Easy soluble in water, virtually nerastvorim in alcohol.

     According to the structure fosfestrol is phosphoric air dietilstilbestrola (see).

     Apply fosfestrol (honvan) for the treatment of prostate gland cancer (including cases with metastases). It is the specific funds operating in all stages of cancer of the localization oestrogenic sensitive to the drugs. In estrogenrezistentnyh form tumors fosfestrol ineffectual.

     Fosfestrol was synthesized to create estrogennogo drug antitumor activity of the election, namely, that he was not active during the circulation of blood, but penetration in Tumor tissue prostate gland situated under the influence of it fosfatazy (which increased activity in tumor cells) with release dietilstilbestrola providing cytostatics influence. Thus, fosfestrol be seen as prolekarstvo performing <transport> functions, ie delivers active substance in Tumor tissue. According to the principle of building, fosfestrol is thus similar to tsiklofosfanom (see).

     Fosfestrol used intravenously in the form of 6% and the solution inside a pill.

     There are different patterns of fosfestrola (honvana). Treatment usually start with a daily intravenous 1, 2 g (4 ampoule of 0.3 g). Enter slowly or kapelno, breeding in 5% glucose solution (with the patient lying down position), for 10 days, followed by 0.3 g (1 vials per day) within 10 to 20 days. In special cases, the long-term daily use of the drug.

     Weakened sick, people with congestive heart failure, a violation of liver and kidney functions, product started to introduce lower-dose 0.6 g (2 ampoule of 0.3 grams) per day for 10 days, followed by 0.3 g (1 vials ) a day.

     Lower doses fosfestrola (honvana) to be carried out under the supervision of clinical and biochemical indicators; To determine fosfatazy acid level in serum.

     If not intravenous shall appoint fosfestrol (honvan) inside in the form of tablets (to the meal with a small amount of liquid).

     Take 3 to 4 tablets (0.1 g of tablet) three times a day. If development diarrhoeic events to detain tablets for oral or language to complete resorption.

     Supportive therapy to appoint one-two tablets three times a day, then one tablet two times a day (at least). It is a supportive therapy injections fosfestrola (honvana) of 0.3 g 4 - 3 - 2 - 1 once a week (under the supervision of clinical and biochemical indicators). You can also supportive therapy appointments prolonged oestrogen drugs (injections poliestradiol- phosphate-estradurina) or oral admission antiandrogenov (see Flutamid).

     Treatment fosfestrolom generally well tolerated by patients. Early treatment sometimes have nausea, vomiting, deterioration of the general condition; These phenomena are in the process of further treatment. Perhaps the emergence of itching and pain in the back passage and genital organs, less frequently, face and neck. In these cases can be applied protivogistaminnye drugs. In the treatment may arise in the area of pain metastaticheskih knots. It may also reduce blood collapse haemorrhagic phenomena. May observed phenomena feminization (Gynecomastia).

     The product contraindications with low blood youngest, the propensity to haemorrhage, expressed in the liver are affected.

     To reduce the recommended closure of the blood in the veins solution of calcium chloride.

     Method of issuance: 6% solution in the ampoule and 5 ml; Pills to 0.1 g in the package of 30 pieces.

     Storage: List B. In sheltered from the world scene.

     Solutions fosfestrola (honvana) can be confused with intravenous fluids containing calcium or magnesium salts.

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