FENILIN (Phenylinum). Fenilindandion 2--1 3.

     Synonyms: Athrombon, Danilone, Dindevane, Diophindane, Emandione, Hedulin, Phenindionum, Phenylindandionum, Pindione, Thromasal, Thrombantin, Thrombophen, Trombosol, Thrombotyl and others.

     White kremovato- or white crystals. Very little soluble in water, poorly soluble in alcohol.

     Refers to a group antikoagulyantov indirect action. By building products group differs from the four-oksikumarina, but the mechanism of close to them; Gipoprotrombinemiyu is associated with the process of education protrombina in the liver is decreased education factors VII, IX, X

     Closure of blood slowing only after fenilina the body; In vitro antikoaguliruyuschego effect the drug has not.

     Reduced concentration factor is the phasing-8 through 10 h and reaches a peak within 24 to 30 h after administration fenilina.

     The cumulative effect is expressed stronger than neodikumarina.

     Indications for use are the same as for neodikumarina. Accepted inside.

     Usually appointed in 1 day in a daily dose of 0,12 - 0,18 g (3 - 4 admission), the two-day in a daily dose of 0,09 - 0,15 g, followed by 0.03-0 , 06 g per day, depending on the content in the blood protrombina.

     Index protrombina support at 50-40%.

     Higher doses for adults inside, off 0.05 g daily 0.2 g.

     To prevent complications tromboembolicheskih appoint 1 to 2 times a day.

     Treatment fenilinom conduct under careful medical supervision with a systematic study of blood and other factors protrombina collapse.

     In acute thrombosis fenilin appointed with heparin.

     Possible complications associated with the impact of phasing of blood, measures to help them and contraindications to the use fenilina are the same as for the derivative 4-oksikumarina.

     Fenilin can cause allergic reactions: dermatitis, increased body temperature, diarrhoea, vomiting, hepatitis, blood oppression.

     When treating fenilinom some patients dying there in the palm of orange color and urine in pink because of the chemical make fenilina (enolnuyu shift in the form) and is not dangerous.

     Method of issuance: powder and pills to 0.03 g.

     Storage: A. Powder list of well-ukuporennoy packaging keeps out of the light; Tablets in sheltered from the world scene.

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