Fenkarol (phencarolum)


FENKAROL (Phencarolum).
     Hinuklidil-3- difenilkarbinola hydrochloride.
     Synonyms: Quifenadine, Quifenadinum.
     The white crystalline powder odourless, bitter taste. Malorastvorim at will and alcohol.
     Fenkarol is original domestic product protivogistaminnym blocking H-1 receptors. With high protivogistaminnoy activity, it is very effective in the treatment of allergic diseases'.
     Fenkarol has low lipofilnostyu poorly permeates through cross the blood-brain barrier and, unlike dimedrola diprazina and has not expressed any sedative and hypnotic action. The product has adrenoliticheskoy and holinoliticheskoy activity.
     There are indications that fenkarol has antiaritmichskoy activity. This is possibly due to the availability of its molecules hinuklidinovogo kernel, as antiaritmicheskoe characteristic of the other derivatives hinuklidina (see Oksilidin).
     On mechanism of fenkarol different from dimedrola protivogistaminnyh and other drugs: it is not only blocking N-1 receptors, but also reduces the content of histamine in tissues because of its ability to activate diaminoksidazu-enzyme, inaktiviruyuschy Histamine.
     Fenkarol malotoksichen. Lack expressed holinoliticheskogo action to appoint him sick, which protivogistaminnye combination drugs with antiholinergicheskoy activity.
     Apply fenkarol with pollinozah, for the treatment of acute and chronic rash, swelling angionevroticheskogo Kvinke, hay fever, allergic rinitov, dermatitis (eczema, neyrodermitov, skin itching, etc.), allergic complications associated with the use of drugs, receiving food, etc. .
     Apply fenkarol inside (after eating). The dose for adults 0,025 - 0.05 g 3 - 4 times a day. The length of treatment depends on the nature of the disease and over; An average of 10 to 20 days. If necessary to repeat courses. Children designate in the following doses: the age of 3 years to 0,005 g 2 - 3 times a day, from 3 to 7 years of 0.01 g 2 times a day, from 7 to 12 years of 0,01 - 0,015 g 2-3 times a day, over 12 years - to 0,025 g 2-3 times a day.
     The product is well tolerated by. In some cases, possible drought in the mouth and diarrhoeic phenomenon going alone or with a decrease in dose.
     Lack expressed sedative effect can enjoy fenkarolom those whose work requires quick physical or mental reaction (transport drivers, etc.) and to counter the use during dimedrola, diprazina protivogistaminnyh and other drugs. Учитывая, однако, возможность индивидуально повышенной чувствительности к препарату, следует до начала систематического лечения установить, не наблюдается ли у больного после приема препарата седативного или снотворного действия.
     Caution is needed in case of the appointment of the drug patients with severe diseases, cardiovascular system, gastrointestinal tract (stomach ulcer disease and stomach cancer in relation to the possible irritation of stomach mucosa), the liver. There are encouraged to nominate fenkarol women in the first three months of pregnancy.
     Form release: pills to 0.01 g (for the child practice), and 0,05 0,025 city
     Storage: List B. In sheltered from the world scene.
     R p. : T ab. Phencaroli 0,025 N. 50
     D.S. At one tablet three times a day (adult)

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