PERINDOPRIL (Perindopril).

     1-Ethyl ether 1-[N-[1-karboksibutil] alanil] geksagidro-2- indolinkarbonovoy acid.

     Synonyms : Kovereks, Prestarium, Coverex, Prestarium.

     Alaninsoderzhaschy ACE inhibitor. The structure is close to ramiprilu. Unlike last built on the basis tsiklopentapirrolokarbonovoy acid fragment contains indolinkarbonovoy acid.

     Perindopril is prolekarstvom; In the body, it is metabolized into the active metabolite perindoprilat.

     Absorbed quickly (1 hour), bioavailability of 65-95%, C max-1 hour (from perindoprilata 3-4 h), T? h-1 (the perindoprilata 24-25 h); display kidneys.

     According to the application perindopril basically similar to other ACE inhibitors : arterial hypertension (including renovaskulyarnaya), chronic heart failure long.

     Assign inside (to food), from 0.002 g (2 mg) one time a day. If necessary dose gradually (at intervals of several weeks) increased to 0,004 grams (with congestive heart failure) or 0,008 grams (with arterial hypertension) 1 every day.

     Side effects (dizziness, headache, disturbed sleep, neuralgia, a violation of taste sensations, settled cough, skin deterioration, increased concentrations of creatinine and urea in the blood) are rare and few expressed.

     The drug is contraindicated in pregnancy and breastfeeding.

     Product : pills for 0,002 and 0,004 grams (2 and 4 mg) (N. 14, 30).

     Noliprel (Noliprel) tablets, containing 0,002 grams (2 mg) and perindoprila or 0.000625 0.00125 grams (0.625 or 1.25 mg) diuretika indapamida (arifona).

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