PERGOLID (Pergolide).

     8 B-[(Metiltio) methyl] -6 - propilergolin monometansulfonat (mesilate).

     Synonym : Permaks, Permax.

     On the chemical structure of the group and has ergolinov elements structural similarities with alkaloids LPV (see Digidroergotamin) and bromokriptinom (see).

     Like bromokriptinu is a motivational D1 and D2- dofamine receptors nigrostriarnoy of the brain; Suppressing the secretion of prolactin.

     Well absorbed in the digestive tract; Displayed mostly kidneys as metabolites.

     Used mainly as a means protivoparkinsonicheskogo.

     Assign inwards from 0.05 1 mg once a day, then (in 2-3 days) dose gradually increased to 0,1-0,25 mg a day to the average daily dose of 3 mg (3 admission).

     Acceptable combination with the drug levodopa (with a lower dose of the latter).

     In applying the drug may : arterial hypotension (especially in the first days of therapy), adults, dizziness, sleep disorders, psoriasis, peripheral oedema, etc.

     To designate caution when arterial hypotension, arrhythmia, psoriasis, in receiving levodopa.

     The drug should not be taken in breast milk (milk enters the mother); When pregnancy is acceptable to the strict application of testimony with caution.

     Enhance effects (including collateral) levodopa; Dopamine antagonists (neuroleptic, metoclopramide) may reduce protivoparkinsonicheskoe pergolida effect.

     Product : pills to 0.00005; 0.000025 and 0,001 g (0.05; 0.25 and 1 mg) (N.10, 30, 100).

     Storage : List B.

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