PENTAZOTSIN (Pentazocinum). (#) 2 - Oxy-5, 9 - dimethyl-2 - (3, 3-dimetilallil) -6, 7-benzomorfan.

     Synonyms : Leksir, Fortral, Dolapent, Fortal, Fortalgesic, Fortral, Fortralin, Lexir, Magadolin, Pentagin, Pentazocine, Sosegon, Sosenyl, Sosigon, Talwin and others.

     Pentazosin-synthetic compounds containing nucleus benzomorfanovoe molecule morphine, but deprived of oxygen bridge and the third shestichlennogo kernel inherent compounds morphine group.

     Nitrogen in piperidinovom nucleus replaced dimetilallilom [CH 2 CH = C (SNz) 2]

     The drug received on a modification of the molecule morphine given that some previously synthesized compounds similar to morphine, but not containing oxygen bridge (Levorfanol or lemorane, etc.), have a high analgeziruyuschey activity; However dimetilallilny balance is an important part of the molecule nalorfina (see), obladayushego largely antagonist properties of morphine. It was assumed that the modification of morphine molecule compounds lead to more analgeziruyuschey activity than nalorfina, but with fewer side effects than morphine. Pentazosin somewhat satisfies these requirements. He has analgeticheskoy activity, although to a lesser degree than morphine, but less depressing respiration, rarely cause constipation and delay urination. Currently available agonisty- antagonists, more than pentazocine (nalbufin etc.).

     Pentazosin well absorbed by ingestion and injection introduction. Peak concentrations in plasma observed after 15 min-1 h after intramuscular introduction and 1 to 3 h after administration of the interior. The half is 2 to 3 hours

     Indications essentially the same as for the morphine.

     For acute pain medication impose parenteral for chronic pain inside.

     Dose for adults under the skin, intramuscularly or intravenously is usually 0.03 g (30 mg), a powerful pain - with 0,045 g (45 mg). Intravenous be slow. If necessary, repeat the introduction into the skin or intramuscularly through 3 -4 hours, intravenously through the 2 - 3 hours

     Inside designate an adult to 0.05 g (50 mg pill = 1) 3 - 4 times a day (for food). In severe pain single dose sometimes increase to 0.1 g.

     Daily intake for adults should not exceed when administered 350 mg.

     Children aged 1 to 6 years are designated drug parenteral : intramuscularly and subcutaneously-to a maximum of 1 mg per 1 kg of body weight / day, intravenous-more than 0.5 mg / kg per day. Children between the ages of 6 and 12 years are designated inwards to 0,025 g (25 mg = 1 / 2 tablets) every 3 to 4 hours

     Pentazocine usually well tolerated. However, there is nausea, vomiting, dizziness, increased sweating, reddening skin, respiratory depression. Sometimes could experience euphoria sputannost consciousness, urinary retention.

     In a sudden halt after a long reception of the drug in relatively high doses may phenomenon abstinence (abdominal cramps, nausea, vomiting, stir, shaking, etc.).

     Pentazosin should be appointed with caution expressed at the lack of liver and kidney. Intravenous drug introduction increases blood pressure, that should be considered in heart attacks, especially among those with hypertension, and peripheral vascular narrowing. It should not be applied pentazocine with craniocerebral injury, accompanied by increasing pressure cerebral spinal fluid, with a propensity to convulsant response, women in the first three months of pregnancy.

     In the long intramuscular drug application to change a place, as the site of injection may seal tissue.

     With regard to the development of events can not be assigned to pentazocine alcohol addicts; Caution should be applied in patients who received high doses of drugs previously analgetikov.

     We should not impose pentazocine a syringe with barbiturates.

     Method of production : tablets of 0.05 g (50 mg) pentazotsina hydrochloride; In 1 ml ampoules containing 0.03 g (30 mg) pentazotsina of lactate.

     Storage : A. Otpuskaetsya list with the same restrictions as analgetiki drugs.

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