PENITSILLINAZA (Penicillinasum).

     Synonym : Neutropen.

     The enzyme, produtsiruemy certain microorganisms.

     The white amorphous powder odourless. The easily soluble in water, gigroskopichen. It contains no less than 50,000 ED 1 mg. Over 1 ED adopted the least amount of preparation that can inaktivirovat 10 -7 mol (ED 60) benzylpenicillin in 1 ml phosphate buffer for 1 h at the temperature of 37 'S.

     Has specific ability inaktivirovat benzylpenicillin and other sensitive to the enzyme penitsilliny. The drug after having a rapid effect : long (4 day) remains in the body, and during that time can have inaktiviruyuschee effect.

     Applied with severe allergies and anaphylactic shock caused by penicillin therapy group (see).

     Enter dose intramuscularly in one million ED immediately after an allergic reaction. If urticaria, or phenomena dermatitis not stihnut through two days, re-impose the same dose of the drug (usually not more than three injections at intervals 2 days).

     Re-introduction should only continuing allergic reaction, which often occurs in the application penitsillinov prolonged action (bitsillinov etc.) [It would impose penitsillinazu in place of prolonged drug penicillin injections. .

     In anaphylactic shock penitsillinazu (1000000 ED) introduced immediately after removing the patient from asphyxia and the collapse generally in these cases means.

     For intramuscular injections to throw out the contents of a bottle or capsules in 2 ml of water for injection or isotonic sodium chloride solution.

     Penitsillinaza with the reintroduction of the organism may cause sensitization and allergic complications, and therefore it should not be applied more than three times in the course of treatment. Assign medication should only allergic reaction caused by penitsillinami (but not other drugs). It should not be used for treatment of occupational penitsillinazu allergic disease in persons employed producing penicillin drugs or long-term work with them (drug use among persons in this category in the case of a severe allergic complications of treatment for their drug penicillin).

     Repeated injections penitsillinazy not receive intolerances with drug and heightened sensitivity to it.

     Product : ukuporennyh in hermetically sealed in bottles or on 500000 and 1000000 ED.

     Storage at room temperature.

Materials allowed to copy only with the active hyperlink to the handbook of medicines